ATP-Dependent Dynamic Protein Aggregation Regulates Bacterial Dormancy Depth Critical for Antibiotic Tolerance

Yingying Pu; Yingxing Li; Xin Jin; Tian Tian; Qi Ma; Ziyi Zhao; Ssu yuan Lin; Zhanghua Chen; Binghui Li; Guang Yao; Mark C. Leake; Chien Jung Lo; Fan Bai

doi:10.1016/j.molcel.2018.10.022

ATP-Dependent Dynamic Protein Aggregation Regulates Bacterial Dormancy Depth Critical for Antibiotic Tolerance

Yingying Pu
, Yingxing Li
, Xin Jin
, Tian Tian
, Qi Ma
, Ziyi Zhao
, Ssu yuan Lin
, Zhanghua Chen
, Binghui Li
, Guang Yao
, Mark C. Leake
, Chien Jung Lo
, Fan Bai

Research output: Contribution to journal › Article › peer-review

273 Scopus citations

Abstract

In this work, Pu et al. introduced a concept of “dormancy depth” that provides a unifying framework for understanding both persisters and viable but non-culturable cells. Subsequent mechanistic investigations revealed how ATP-dependent dynamic protein aggregation regulates cellular dormancy and resuscitation, the fine control of which facilitates bacterial drug tolerance.

Original language	English (US)
Pages (from-to)	143-156.e4
Journal	Molecular cell
Volume	73
Issue number	1
DOIs	https://doi.org/10.1016/j.molcel.2018.10.022
State	Published - Jan 3 2019

Keywords

ATP
DnaK-ClpB complex
bacterial antibiotic tolerance
cell resuscitation
dormancy depth
persisters
protein aggregates
viable but non-culturable cells

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2018.10.022

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title = "ATP-Dependent Dynamic Protein Aggregation Regulates Bacterial Dormancy Depth Critical for Antibiotic Tolerance",

abstract = "In this work, Pu et al. introduced a concept of “dormancy depth” that provides a unifying framework for understanding both persisters and viable but non-culturable cells. Subsequent mechanistic investigations revealed how ATP-dependent dynamic protein aggregation regulates cellular dormancy and resuscitation, the fine control of which facilitates bacterial drug tolerance.",

keywords = "ATP, DnaK-ClpB complex, bacterial antibiotic tolerance, cell resuscitation, dormancy depth, persisters, protein aggregates, viable but non-culturable cells",

author = "Yingying Pu and Yingxing Li and Xin Jin and Tian Tian and Qi Ma and Ziyi Zhao and Lin, \{Ssu yuan\} and Zhanghua Chen and Binghui Li and Guang Yao and Leake, \{Mark C.\} and Lo, \{Chien Jung\} and Fan Bai",

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year = "2019",

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doi = "10.1016/j.molcel.2018.10.022",

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T1 - ATP-Dependent Dynamic Protein Aggregation Regulates Bacterial Dormancy Depth Critical for Antibiotic Tolerance

AU - Pu, Yingying

AU - Li, Yingxing

AU - Jin, Xin

AU - Tian, Tian

AU - Ma, Qi

AU - Zhao, Ziyi

AU - Lin, Ssu yuan

AU - Chen, Zhanghua

AU - Li, Binghui

AU - Yao, Guang

AU - Leake, Mark C.

AU - Lo, Chien Jung

AU - Bai, Fan

PY - 2019/1/3

Y1 - 2019/1/3

N2 - In this work, Pu et al. introduced a concept of “dormancy depth” that provides a unifying framework for understanding both persisters and viable but non-culturable cells. Subsequent mechanistic investigations revealed how ATP-dependent dynamic protein aggregation regulates cellular dormancy and resuscitation, the fine control of which facilitates bacterial drug tolerance.

AB - In this work, Pu et al. introduced a concept of “dormancy depth” that provides a unifying framework for understanding both persisters and viable but non-culturable cells. Subsequent mechanistic investigations revealed how ATP-dependent dynamic protein aggregation regulates cellular dormancy and resuscitation, the fine control of which facilitates bacterial drug tolerance.

KW - ATP

KW - DnaK-ClpB complex

KW - bacterial antibiotic tolerance

KW - cell resuscitation

KW - dormancy depth

KW - persisters

KW - protein aggregates

KW - viable but non-culturable cells

UR - https://www.scopus.com/pages/publications/85059498929

UR - https://www.scopus.com/pages/publications/85059498929#tab=citedBy

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DO - 10.1016/j.molcel.2018.10.022

M3 - Article

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AN - SCOPUS:85059498929

SN - 1097-2765

VL - 73

SP - 143-156.e4

JO - Molecular cell

JF - Molecular cell

IS - 1

ER -

ATP-Dependent Dynamic Protein Aggregation Regulates Bacterial Dormancy Depth Critical for Antibiotic Tolerance

Abstract

Keywords

ASJC Scopus subject areas

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