@article{a61a73b79426449a8a250292397dd0a9,
title = "ATP-Dependent Dynamic Protein Aggregation Regulates Bacterial Dormancy Depth Critical for Antibiotic Tolerance",
abstract = "In this work, Pu et al. introduced a concept of “dormancy depth” that provides a unifying framework for understanding both persisters and viable but non-culturable cells. Subsequent mechanistic investigations revealed how ATP-dependent dynamic protein aggregation regulates cellular dormancy and resuscitation, the fine control of which facilitates bacterial drug tolerance.",
keywords = "ATP, DnaK-ClpB complex, bacterial antibiotic tolerance, cell resuscitation, dormancy depth, persisters, protein aggregates, viable but non-culturable cells",
author = "Yingying Pu and Yingxing Li and Xin Jin and Tian Tian and Qi Ma and Ziyi Zhao and Lin, {Ssu yuan} and Zhanghua Chen and Binghui Li and Guang Yao and Leake, {Mark C.} and Lo, {Chien Jung} and Fan Bai",
note = "Funding Information: We thank Profs. Xiaoliang Sunney Xie and Xiaowei Zhuang (Harvard University) for valuable discussions, and Drs. Teuta Pilizota, Alexander F. McVey, and Ekaterina Krasnopeeva (The University of Edinburgh) for providing the pH sensor strain EK07. We also thank the Core Facilities at School of Life Sciences, Peking University for assistance with mass spectrometry and Dong Liu for her help with MS data analysis. This work was financially supported by the National Natural Science Foundation of China (No. 31722003, No. 31770925, No. 31370847) to F. B.; the MRC (grant MR/K01580X/1), BBSRC (grant BB/N006453/1), and EC (Project ID: 764591) to M.C.L.; and the National Science and Technology Major Project (No. 2017ZX10304402) to Y.P. F.B. and C.-J.L. are also supported by the Human Frontier Science Program grant (RGP 0041/2015). Funding Information: We thank Profs. Xiaoliang Sunney Xie and Xiaowei Zhuang (Harvard University) for valuable discussions, and Drs. Teuta Pilizota, Alexander F. McVey, and Ekaterina Krasnopeeva (The University of Edinburgh) for providing the pH sensor strain EK07. We also thank the Core Facilities at School of Life Sciences, Peking University for assistance with mass spectrometry and Dong Liu for her help with MS data analysis. This work was financially supported by the National Natural Science Foundation of China (No. 31722003 , No. 31770925 , No. 31370847 ) to F. B.; the MRC (grant MR/K01580X/1 ), BBSRC (grant BB/N006453/1 ), and EC (Project ID: 764591 ) to M.C.L.; and the National Science and Technology Major Project (No. 2017ZX10304402 ) to Y.P. F.B. and C.-J.L. are also supported by the Human Frontier Science Program grant ( RGP 0041/2015 ). Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2019",
month = jan,
day = "3",
doi = "10.1016/j.molcel.2018.10.022",
language = "English (US)",
volume = "73",
pages = "143--156.e4",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "1",
}