Atomic force microscopy of electrospun organic-inorganic lipid nanofibers

Jinhong Zhang; Celine Cohn; Weiguo Qiu; Zhengbao Zha; Zhifei Dai; Xiaoyi Wu

doi:10.1063/1.3635783

Atomic force microscopy of electrospun organic-inorganic lipid nanofibers

Jinhong Zhang, Celine Cohn, Weiguo Qiu, Zhengbao Zha, Zhifei Dai, Xiaoyi Wu

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

An organic-inorganic hybridization strategy has been proposed to synthesize polymerizable lipid-based materials for the creation of highly stable lipid-mimetic nanostructures. We employ atomic force microscopy (AFM) to analyze the surface morphology and mechanical property of electrospun cholesteryl-succinyl silane (CSS) nanofibers. The AFM nanoindentation of the CSS nanofibers reveals elastic moduli of 55.3±27.6 to 70.8±35 MPa, which is significantly higher than the moduli of natural phospholipids and cholesterols. The study shows that organic-inorganic hybridization is useful in the design of highly stable lipid-based materials.

Original language	English (US)
Article number	103702
Journal	Applied Physics Letters
Volume	99
Issue number	10
DOIs	https://doi.org/10.1063/1.3635783
State	Published - Sep 5 2011

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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title = "Atomic force microscopy of electrospun organic-inorganic lipid nanofibers",

abstract = "An organic-inorganic hybridization strategy has been proposed to synthesize polymerizable lipid-based materials for the creation of highly stable lipid-mimetic nanostructures. We employ atomic force microscopy (AFM) to analyze the surface morphology and mechanical property of electrospun cholesteryl-succinyl silane (CSS) nanofibers. The AFM nanoindentation of the CSS nanofibers reveals elastic moduli of 55.3±27.6 to 70.8±35 MPa, which is significantly higher than the moduli of natural phospholipids and cholesterols. The study shows that organic-inorganic hybridization is useful in the design of highly stable lipid-based materials.",

author = "Jinhong Zhang and Celine Cohn and Weiguo Qiu and Zhengbao Zha and Zhifei Dai and Xiaoyi Wu",

note = "Funding Information: This work was supported by the US National Institutes of Health (R21EB009801) and National Science Foundation (CMMI0856215), the National High-Tech R&D Program (No.2007AA03Z316), and National Science Foundation of China (30970829).",

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AU - Zhang, Jinhong

AU - Cohn, Celine

AU - Qiu, Weiguo

AU - Zha, Zhengbao

AU - Dai, Zhifei

AU - Wu, Xiaoyi

N1 - Funding Information: This work was supported by the US National Institutes of Health (R21EB009801) and National Science Foundation (CMMI0856215), the National High-Tech R&D Program (No.2007AA03Z316), and National Science Foundation of China (30970829).

PY - 2011/9/5

Y1 - 2011/9/5

N2 - An organic-inorganic hybridization strategy has been proposed to synthesize polymerizable lipid-based materials for the creation of highly stable lipid-mimetic nanostructures. We employ atomic force microscopy (AFM) to analyze the surface morphology and mechanical property of electrospun cholesteryl-succinyl silane (CSS) nanofibers. The AFM nanoindentation of the CSS nanofibers reveals elastic moduli of 55.3±27.6 to 70.8±35 MPa, which is significantly higher than the moduli of natural phospholipids and cholesterols. The study shows that organic-inorganic hybridization is useful in the design of highly stable lipid-based materials.

AB - An organic-inorganic hybridization strategy has been proposed to synthesize polymerizable lipid-based materials for the creation of highly stable lipid-mimetic nanostructures. We employ atomic force microscopy (AFM) to analyze the surface morphology and mechanical property of electrospun cholesteryl-succinyl silane (CSS) nanofibers. The AFM nanoindentation of the CSS nanofibers reveals elastic moduli of 55.3±27.6 to 70.8±35 MPa, which is significantly higher than the moduli of natural phospholipids and cholesterols. The study shows that organic-inorganic hybridization is useful in the design of highly stable lipid-based materials.

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Atomic force microscopy of electrospun organic-inorganic lipid nanofibers

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