Atherosclerosis and cancer: Flip sides of the neoplastic response in mammalian cells?

Kenneth S. Ramos; Charles R. Partridge

doi:10.1385/CT:5:3:245

Atherosclerosis and cancer: Flip sides of the neoplastic response in mammalian cells?

Kenneth S. Ramos, Charles R. Partridge

Medicine

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Scientific and medical evidence over the past 30 years has established striking parallels between atherosclerosis and cancer - pathogenetic relationships that cross the boundaries of fiction into the realm of reason. Both diseases in humans are characterized by uncontrolled regulation of cellular growth and differentiation and share many common genomic targets during the course of growth dysregulation. Such parallels can be reconciled if atherosclerotic plaques are viewed as neoplasms of smooth muscle origin.

Original language	English (US)
Pages (from-to)	245-255
Number of pages	11
Journal	Cardiovascular toxicology
Volume	5
Issue number	3
DOIs	https://doi.org/10.1385/CT:5:3:245
State	Published - Sep 2005

Keywords

Atherosclerosis
Cancer
Chemical carcinogens
Environmental disease
Neoplasia

ASJC Scopus subject areas

Molecular Biology
Toxicology
Cardiology and Cardiovascular Medicine

Access to Document

10.1385/CT:5:3:245

Cite this

@article{9b0c5fbc07d24bfb90bea2aca6b97546,

title = "Atherosclerosis and cancer: Flip sides of the neoplastic response in mammalian cells?",

abstract = "Scientific and medical evidence over the past 30 years has established striking parallels between atherosclerosis and cancer - pathogenetic relationships that cross the boundaries of fiction into the realm of reason. Both diseases in humans are characterized by uncontrolled regulation of cellular growth and differentiation and share many common genomic targets during the course of growth dysregulation. Such parallels can be reconciled if atherosclerotic plaques are viewed as neoplasms of smooth muscle origin.",

keywords = "Atherosclerosis, Cancer, Chemical carcinogens, Environmental disease, Neoplasia",

author = "Ramos, {Kenneth S.} and Partridge, {Charles R.}",

year = "2005",

month = sep,

doi = "10.1385/CT:5:3:245",

language = "English (US)",

volume = "5",

pages = "245--255",

journal = "Cardiovascular toxicology",

issn = "1530-7905",

publisher = "Springer",

number = "3",

}

TY - JOUR

T1 - Atherosclerosis and cancer

T2 - Flip sides of the neoplastic response in mammalian cells?

AU - Ramos, Kenneth S.

AU - Partridge, Charles R.

PY - 2005/9

Y1 - 2005/9

N2 - Scientific and medical evidence over the past 30 years has established striking parallels between atherosclerosis and cancer - pathogenetic relationships that cross the boundaries of fiction into the realm of reason. Both diseases in humans are characterized by uncontrolled regulation of cellular growth and differentiation and share many common genomic targets during the course of growth dysregulation. Such parallels can be reconciled if atherosclerotic plaques are viewed as neoplasms of smooth muscle origin.

AB - Scientific and medical evidence over the past 30 years has established striking parallels between atherosclerosis and cancer - pathogenetic relationships that cross the boundaries of fiction into the realm of reason. Both diseases in humans are characterized by uncontrolled regulation of cellular growth and differentiation and share many common genomic targets during the course of growth dysregulation. Such parallels can be reconciled if atherosclerotic plaques are viewed as neoplasms of smooth muscle origin.

KW - Atherosclerosis

KW - Cancer

KW - Chemical carcinogens

KW - Environmental disease

KW - Neoplasia

UR - http://www.scopus.com/inward/record.url?scp=27144515557&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27144515557&partnerID=8YFLogxK

U2 - 10.1385/CT:5:3:245

DO - 10.1385/CT:5:3:245

M3 - Article

C2 - 16244370

AN - SCOPUS:27144515557

SN - 1530-7905

VL - 5

SP - 245

EP - 255

JO - Cardiovascular toxicology

JF - Cardiovascular toxicology

IS - 3

ER -

Atherosclerosis and cancer: Flip sides of the neoplastic response in mammalian cells?

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this