Asymmetric synthesis of unusual amino acids: An enantioselective synthesis of the four isomers of D- and L-O-Methyl-2′, β-Dimethyltyrosine

Guigen Li; Keith C. Russell; Mark A. Jarosinski; Victor J. Hruby

doi:10.1016/S0040-4039(00)77626-X

Asymmetric synthesis of unusual amino acids: An enantioselective synthesis of the four isomers of D- and L-O-Methyl-2′, β-Dimethyltyrosine

Guigen Li, Keith C. Russell, Mark A. Jarosinski, Victor J. Hruby

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

The four individual isomers of D- and L-O-methyl-2′, β-dimethyltyrosines have been synthesized in high optical purity. The evidence for asymmetric induction was cofirmed by the X-ray analysis of one of the key intermediates.

Original language	English (US)
Pages (from-to)	2565-2568
Number of pages	4
Journal	Tetrahedron Letters
Volume	34
Issue number	16
DOIs	https://doi.org/10.1016/S0040-4039(00)77626-X
State	Published - Apr 16 1993

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)77626-X

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title = "Asymmetric synthesis of unusual amino acids: An enantioselective synthesis of the four isomers of D- and L-O-Methyl-2′, β-Dimethyltyrosine",

abstract = "The four individual isomers of D- and L-O-methyl-2′, β-dimethyltyrosines have been synthesized in high optical purity. The evidence for asymmetric induction was cofirmed by the X-ray analysis of one of the key intermediates.",

author = "Guigen Li and Russell, {Keith C.} and Jarosinski, {Mark A.} and Hruby, {Victor J.}",

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T2 - An enantioselective synthesis of the four isomers of D- and L-O-Methyl-2′, β-Dimethyltyrosine

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AU - Russell, Keith C.

AU - Jarosinski, Mark A.

AU - Hruby, Victor J.

PY - 1993/4/16

Y1 - 1993/4/16

N2 - The four individual isomers of D- and L-O-methyl-2′, β-dimethyltyrosines have been synthesized in high optical purity. The evidence for asymmetric induction was cofirmed by the X-ray analysis of one of the key intermediates.

AB - The four individual isomers of D- and L-O-methyl-2′, β-dimethyltyrosines have been synthesized in high optical purity. The evidence for asymmetric induction was cofirmed by the X-ray analysis of one of the key intermediates.

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Asymmetric synthesis of unusual amino acids: An enantioselective synthesis of the four isomers of D- and L-O-Methyl-2′, β-Dimethyltyrosine

Abstract

ASJC Scopus subject areas

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