Asymmetric synthesis of unusual amino acid: Synthesis of four isomers of β-methyl-3-(2'-naphthyl)alanine

Wei Yuan; Victor J. Hruby

doi:10.1016/S0040-4039(97)00770-3

Asymmetric synthesis of unusual amino acid: Synthesis of four isomers of β-methyl-3-(2'-naphthyl)alanine

Wei Yuan, Victor J. Hruby

Chemistry and Biochemistry

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24 Scopus citations

Abstract

The synthesis of all four individual isomers of 3-methyl-3-(2'-naphthyl)analine was accomplished using asymmetric conjugate 1,4-addition followed by direct or indirect azidation using an Evans-type chiral auxiliary (4-phenyl-2-oxazolidinone).

Original language	English (US)
Pages (from-to)	3853-3856
Number of pages	4
Journal	Tetrahedron Letters
Volume	38
Issue number	22
DOIs	https://doi.org/10.1016/S0040-4039(97)00770-3
State	Published - Jun 2 1997

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(97)00770-3

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title = "Asymmetric synthesis of unusual amino acid: Synthesis of four isomers of β-methyl-3-(2'-naphthyl)alanine",

abstract = "The synthesis of all four individual isomers of 3-methyl-3-(2'-naphthyl)analine was accomplished using asymmetric conjugate 1,4-addition followed by direct or indirect azidation using an Evans-type chiral auxiliary (4-phenyl-2-oxazolidinone).",

author = "Wei Yuan and Hruby, {Victor J.}",

note = "Funding Information: Supported in part by grants from the US Public Heaith Services DK 17420and NIDA",

year = "1997",

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doi = "10.1016/S0040-4039(97)00770-3",

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T2 - Synthesis of four isomers of β-methyl-3-(2'-naphthyl)alanine

AU - Yuan, Wei

AU - Hruby, Victor J.

N1 - Funding Information: Supported in part by grants from the US Public Heaith Services DK 17420and NIDA

PY - 1997/6/2

Y1 - 1997/6/2

N2 - The synthesis of all four individual isomers of 3-methyl-3-(2'-naphthyl)analine was accomplished using asymmetric conjugate 1,4-addition followed by direct or indirect azidation using an Evans-type chiral auxiliary (4-phenyl-2-oxazolidinone).

AB - The synthesis of all four individual isomers of 3-methyl-3-(2'-naphthyl)analine was accomplished using asymmetric conjugate 1,4-addition followed by direct or indirect azidation using an Evans-type chiral auxiliary (4-phenyl-2-oxazolidinone).

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U2 - 10.1016/S0040-4039(97)00770-3

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JO - Tetrahedron Letters

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SN - 0040-4039

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ER -

Asymmetric synthesis of unusual amino acid: Synthesis of four isomers of β-methyl-3-(2'-naphthyl)alanine

Abstract

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