Asymmetric synthesis of topographically constrained amino acids: synthesis of the optically pure isomers of α,β-dimethyl-phenylalanine and α,β-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Wieslaw M. Kazmierski; Victor J. Hruby

doi:10.1016/S0040-4039(00)93551-2

Asymmetric synthesis of topographically constrained amino acids: synthesis of the optically pure isomers of α,β-dimethyl-phenylalanine and α,β-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Wieslaw M. Kazmierski
, Victor J. Hruby

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

All four isomers of α,β-dimethylphenylalanine and α,β-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid have been synthesized in high optical purity for use in the design of topographically constrained peptides.

Original language	English (US)
Pages (from-to)	5769-5772
Number of pages	4
Journal	Tetrahedron Letters
Volume	32
Issue number	41
DOIs	https://doi.org/10.1016/S0040-4039(00)93551-2
State	Published - Oct 7 1991
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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Asymmetric synthesis of topographically constrained amino acids: synthesis of the optically pure isomers of α,β-dimethyl-phenylalanine and α,β-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid. / Kazmierski, Wieslaw M.; Hruby, Victor J.
In: Tetrahedron Letters, Vol. 32, No. 41, 07.10.1991, p. 5769-5772.

Research output: Contribution to journal › Article › peer-review

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abstract = "All four isomers of α,β-dimethylphenylalanine and α,β-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid have been synthesized in high optical purity for use in the design of topographically constrained peptides.",

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Asymmetric synthesis of topographically constrained amino acids: synthesis of the optically pure isomers of α,β-dimethyl-phenylalanine and α,β-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Abstract

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