Asymmetric synthesis of isoquinolinonaphthyridines catalyzed by a chiral Brønsted acid

Jianjun Li; Yiwei Fu; Cong Qin; Yang Yu; Hao Li; Wei Wang

doi:10.1039/c7ob01527e

Asymmetric synthesis of isoquinolinonaphthyridines catalyzed by a chiral Brønsted acid

Jianjun Li
, Yiwei Fu
, Cong Qin
, Yang Yu
, Hao Li
, Wei Wang

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

A catalytic asymmetric method for the synthesis of chiral isoquinolinonaphthyridines has been developed. A chiral disulfonimide catalyzes a redox cyclization reaction between 2-methyl-3-aldehydeazaarenes and 1,2,3,4-tetrahydroisoquinolines to deliver a range of isoquinolinonaphthyridines with good to high yields (up to 91%) and up to 92:8 er.

Original language	English (US)
Pages (from-to)	6474-6477
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	15
Issue number	31
DOIs	https://doi.org/10.1039/c7ob01527e
State	Published - 2017
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c7ob01527e

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@article{42102b3fb47d46aa996b05c37803879e,

title = "Asymmetric synthesis of isoquinolinonaphthyridines catalyzed by a chiral Br{\o}nsted acid",

abstract = "A catalytic asymmetric method for the synthesis of chiral isoquinolinonaphthyridines has been developed. A chiral disulfonimide catalyzes a redox cyclization reaction between 2-methyl-3-aldehydeazaarenes and 1,2,3,4-tetrahydroisoquinolines to deliver a range of isoquinolinonaphthyridines with good to high yields (up to 91\%) and up to 92:8 er.",

author = "Jianjun Li and Yiwei Fu and Cong Qin and Yang Yu and Hao Li and Wei Wang",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (21372073, 21572054 and 21572055), the Fundamental Research Funds for the Central Universities and the China 111 Project (Grant B07023). Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

year = "2017",

doi = "10.1039/c7ob01527e",

language = "English (US)",

volume = "15",

pages = "6474--6477",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "31",

}

TY - JOUR

T1 - Asymmetric synthesis of isoquinolinonaphthyridines catalyzed by a chiral Brønsted acid

AU - Li, Jianjun

AU - Fu, Yiwei

AU - Qin, Cong

AU - Yu, Yang

AU - Li, Hao

AU - Wang, Wei

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (21372073, 21572054 and 21572055), the Fundamental Research Funds for the Central Universities and the China 111 Project (Grant B07023). Publisher Copyright: © 2017 The Royal Society of Chemistry.

PY - 2017

Y1 - 2017

N2 - A catalytic asymmetric method for the synthesis of chiral isoquinolinonaphthyridines has been developed. A chiral disulfonimide catalyzes a redox cyclization reaction between 2-methyl-3-aldehydeazaarenes and 1,2,3,4-tetrahydroisoquinolines to deliver a range of isoquinolinonaphthyridines with good to high yields (up to 91%) and up to 92:8 er.

AB - A catalytic asymmetric method for the synthesis of chiral isoquinolinonaphthyridines has been developed. A chiral disulfonimide catalyzes a redox cyclization reaction between 2-methyl-3-aldehydeazaarenes and 1,2,3,4-tetrahydroisoquinolines to deliver a range of isoquinolinonaphthyridines with good to high yields (up to 91%) and up to 92:8 er.

UR - https://www.scopus.com/pages/publications/85027238638

UR - https://www.scopus.com/pages/publications/85027238638#tab=citedBy

U2 - 10.1039/c7ob01527e

DO - 10.1039/c7ob01527e

M3 - Article

C2 - 28737793

AN - SCOPUS:85027238638

SN - 1477-0520

VL - 15

SP - 6474

EP - 6477

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 31

ER -

Asymmetric synthesis of isoquinolinonaphthyridines catalyzed by a chiral Brønsted acid

Abstract

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