Asymmetric synthesis of isoquinolinonaphthyridines catalyzed by a chiral Brønsted acid

Jianjun Li, Yiwei Fu, Cong Qin, Yang Yu, Hao Li, Wei Wang

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

A catalytic asymmetric method for the synthesis of chiral isoquinolinonaphthyridines has been developed. A chiral disulfonimide catalyzes a redox cyclization reaction between 2-methyl-3-aldehydeazaarenes and 1,2,3,4-tetrahydroisoquinolines to deliver a range of isoquinolinonaphthyridines with good to high yields (up to 91%) and up to 92:8 er.

Original languageEnglish (US)
Pages (from-to)6474-6477
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume15
Issue number31
DOIs
StatePublished - 2017
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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