Asymmetric syntheses of highly hydrophobic chimeric aromatic amino acids: 2-Amino-3,3'-diarylpropionic acids

Jun Lin; Subo Liao; Victor J. Hruby

doi:10.1016/S0040-4039(98)00516-4

Asymmetric syntheses of highly hydrophobic chimeric aromatic amino acids: 2-Amino-3,3'-diarylpropionic acids

Jun Lin
, Subo Liao
, Victor J. Hruby

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Four conformationally constrained, highly hydrophobic, and enantiomerically pure chimeric aromatic amino acids have been asymmetrically synthesized in 7 steps with overall yields of 20-30%.

Original language	English (US)
Pages (from-to)	3117-3120
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	20
DOIs	https://doi.org/10.1016/S0040-4039(98)00516-4
State	Published - May 14 1998
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(98)00516-4

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title = "Asymmetric syntheses of highly hydrophobic chimeric aromatic amino acids: 2-Amino-3,3'-diarylpropionic acids",

abstract = "Four conformationally constrained, highly hydrophobic, and enantiomerically pure chimeric aromatic amino acids have been asymmetrically synthesized in 7 steps with overall yields of 20-30\%.",

author = "Jun Lin and Subo Liao and Hruby, \{Victor J.\}",

note = "Funding Information: The authors wish to acknowledge the financial support of grants from NIDA DA 06284 and the U.S. Public Health Service DK 17420, the financial support from Yunnan Provincial Education Committee, P.R.C. for J.L. as visiting scholar in the U.S.A., the Dean's Fellowship from the Graduate College of the University of Arizona for S.L. The contents of this paper are solely the responsibility of the authors and do not necessarily represent the official views of the USPHS.",

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AU - Lin, Jun

AU - Liao, Subo

AU - Hruby, Victor J.

N1 - Funding Information: The authors wish to acknowledge the financial support of grants from NIDA DA 06284 and the U.S. Public Health Service DK 17420, the financial support from Yunnan Provincial Education Committee, P.R.C. for J.L. as visiting scholar in the U.S.A., the Dean's Fellowship from the Graduate College of the University of Arizona for S.L. The contents of this paper are solely the responsibility of the authors and do not necessarily represent the official views of the USPHS.

PY - 1998/5/14

Y1 - 1998/5/14

N2 - Four conformationally constrained, highly hydrophobic, and enantiomerically pure chimeric aromatic amino acids have been asymmetrically synthesized in 7 steps with overall yields of 20-30%.

AB - Four conformationally constrained, highly hydrophobic, and enantiomerically pure chimeric aromatic amino acids have been asymmetrically synthesized in 7 steps with overall yields of 20-30%.

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DO - 10.1016/S0040-4039(98)00516-4

M3 - Article

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ER -

Asymmetric syntheses of highly hydrophobic chimeric aromatic amino acids: 2-Amino-3,3'-diarylpropionic acids

Abstract

ASJC Scopus subject areas

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