Asthma heterogeneity and severity

Tara F. Carr, Eugene Bleecker

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations

Abstract

Asthma is a common, chronic inflammatory airways disease characterized by a clinical syndrome of bronchial hyperresponsiveness, inflammation, and reversible airflow obstruction. Individuals with asthma can vary widely in clinical presentation, severity, and pathobiology. The incident factors, pathogenesis, prognosis, and treatment of asthma remain incompletely understood. Utilizing measurable characteristics of asthmatic patients, including demographic, physiologic, and biologic markers, can however identify meaningful phenotypic categories in asthma. Identification of these phenotypes may help improve precision therapeutics targeted toward an individual's' disease, and may identify strategies for preventing progression of disease severity.

Original languageEnglish (US)
Article number41
JournalWorld Allergy Organization Journal
Volume9
Issue number1
DOIs
StatePublished - Nov 29 2016
Externally publishedYes

Keywords

  • Heterogeneity
  • Phenotype
  • Severe asthma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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