TY - JOUR
T1 - Asthma control, adiposity, and adipokines among inner-city adolescents
AU - Kattan, Meyer
AU - Kumar, Rajesh
AU - Bloomberg, Gordon R.
AU - Mitchell, Herman E.
AU - Calatroni, Agustin
AU - Gergen, Peter J.
AU - Kercsmar, Carolyn M.
AU - Visness, Cynthia M.
AU - Matsui, Elizabeth C.
AU - Steinbach, Suzanne F.
AU - Szefler, Stanley J.
AU - Sorkness, Christine A.
AU - Morgan, Wayne J.
AU - Teach, Stephen J.
AU - Gan, Vanthaya N.
PY - 2010/3
Y1 - 2010/3
N2 - Background: There is an association between adiposity and asthma prevalence, but the relationship to asthma control is unclear. Objectives: We sought to understand the relationships among adiposity, sex, and asthma control in inner-city adolescents with asthma. Methods: We prospectively followed 368 adolescents with moderate-to-severe asthma (ages 12-20 years) living in 10 urban areas for 1 year. Asthma symptoms and exacerbations were recorded, and pulmonary function and exhaled nitric oxide levels were measured every 6 weeks. Adiposity measures (body mass index [BMI] and dual-energy X-ray absorptiometric scans) were made, and blood was collected for measurement of allergy markers, adiponectin, leptin, TNF-α, IL-6, and C-reactive protein levels. Results: More than 60% of female subjects and 50% of male subjects were above the 85th percentile of BMI for age. Higher BMI was associated with more symptom days (R = 0.18, P = .02) and exacerbations (R = 0.18, P = .06) among female subjects only. Adiponectin was inversely related to asthma symptoms (R = -0.18, P < .05) and exacerbations (R = -0.20, P < .05) and positively with FEV1/forced vital capacity ratio (R = 0.15, P < .05) in male subjects only independent of body size. There was no relationship between adiposity or adipokines and total IgE levels, blood eosinophil counts, and exhaled nitric oxide levels. Dual-energy X-ray absorptiometry provided little additional value in relating adiposity to asthma outcome in this population of adolescents. Conclusion: Adiposity is associated with poorer asthma control in female subjects. Adiponectin is associated with improved asthma control in male subjects.
AB - Background: There is an association between adiposity and asthma prevalence, but the relationship to asthma control is unclear. Objectives: We sought to understand the relationships among adiposity, sex, and asthma control in inner-city adolescents with asthma. Methods: We prospectively followed 368 adolescents with moderate-to-severe asthma (ages 12-20 years) living in 10 urban areas for 1 year. Asthma symptoms and exacerbations were recorded, and pulmonary function and exhaled nitric oxide levels were measured every 6 weeks. Adiposity measures (body mass index [BMI] and dual-energy X-ray absorptiometric scans) were made, and blood was collected for measurement of allergy markers, adiponectin, leptin, TNF-α, IL-6, and C-reactive protein levels. Results: More than 60% of female subjects and 50% of male subjects were above the 85th percentile of BMI for age. Higher BMI was associated with more symptom days (R = 0.18, P = .02) and exacerbations (R = 0.18, P = .06) among female subjects only. Adiponectin was inversely related to asthma symptoms (R = -0.18, P < .05) and exacerbations (R = -0.20, P < .05) and positively with FEV1/forced vital capacity ratio (R = 0.15, P < .05) in male subjects only independent of body size. There was no relationship between adiposity or adipokines and total IgE levels, blood eosinophil counts, and exhaled nitric oxide levels. Dual-energy X-ray absorptiometry provided little additional value in relating adiposity to asthma outcome in this population of adolescents. Conclusion: Adiposity is associated with poorer asthma control in female subjects. Adiponectin is associated with improved asthma control in male subjects.
KW - Obesity
KW - adipokines
KW - adiponectin
KW - asthma
KW - leptin
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U2 - 10.1016/j.jaci.2010.01.053
DO - 10.1016/j.jaci.2010.01.053
M3 - Article
C2 - 20226295
AN - SCOPUS:77649245488
SN - 0091-6749
VL - 125
SP - 584
EP - 592
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 3
ER -