Associations Among Sex, Cognitive Ability, and Autism Symptoms in Individuals with Down Syndrome

Laura del Hoyo Soriano, Audra Sterling, Jamie Edgin, Debra R. Hamilton, Elizabeth Berry-Kravis, Amanda Dimachkie Nunnally, Angela John Thurman, Leonard Abbeduto

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


This study explores sex-differences in (a) rates and profiles of autism symptoms as well as in (b) the contribution of intellectual quotient (IQ) to autism symptom presentation in Down syndrome (DS). Participants were 40 males and 38 females with DS, aged 6 to 23 years. Autism symptoms were rated through the Autism Diagnostic Observation Schedule-Second Edition (ADOS-2). Results show no sex differences in the ADOS-2 Calibrated Severity Scores (CSS). However, only females with DS who are classified as DS-Only have higher scores on verbal IQ than those classified as DS + autism. Furthermore, associations between IQ and all CSSs are found for females, but not for males. Findings suggest that verbal cognition may play differential roles for females and males with DS.

Original languageEnglish (US)
Pages (from-to)301-311
Number of pages11
JournalJournal of Autism and Developmental Disorders
Issue number1
StatePublished - Jan 2024


  • Autism
  • Cognitive ability
  • Down syndrome
  • Females
  • Sex-differences

ASJC Scopus subject areas

  • Developmental and Educational Psychology


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