@article{7229a6343a3744238ad2af4cb82f6868,
title = "Association of West African ancestry and blood pressure control among African Americans taking antihypertensive medication in the Jackson Heart Study",
abstract = "African Americans have a wide range of continental genetic ancestry. It is unclear whether racial differences in blood pressure (BP) control are related to ancestral background. The authors analyzed data from the Jackson Heart Study, a cohort exclusively comprised of self-identified African Americans, to assess the association between estimated West African ancestry (WAA) and BP control (systolic and diastolic BP < 140/90 mm Hg). Three nested modified Poisson regression models were used to calculate prevalence ratios for BP control associated with the three upper quartiles, separately, vs the lowest quartile of West African ancestry. The authors analyzed data from 1658 participants with hypertension who reported taking all of their antihypertensive medications in the previous 24 hours. WAA was estimated using 389 ancestry informative markers and categorized into quartiles (Q1: <73.7%, Q2: >73.7%-81.0%, Q3: >81.0%-86.3%, and Q4: >86.3%). The proportion of participants with controlled BP in the lowest-to-highest WAA quartile was 75.2%, 76.1%, 76.6%, and 74.4%. The prevalence ratios (95% CI) for controlled BP comparing Q2, Q3, and Q4 to Q1 of WAA were 1.00 (0.93-1.08), 1.02 (0.94-1.10), and 0.99 (0.91-1.07), respectively. Among African Americans in the Jackson Heart Study taking antihypertensive medication, BP control rates did not differ across quartiles of WAA.",
keywords = "African Americans, blood pressure control, hypertension, medication, treatment",
author = "{Van Tassell}, {Jon C.} and Daichi Shimbo and Rachel Hess and Rick Kittles and Wilson, {James G.} and Jorde, {Lynn B.} and Man Li and Lange, {Leslie A.} and Lange, {Ethan M.} and Paul Muntner and Bress, {Adam P.}",
note = "Funding Information: The Jackson Heart Study (JHS) is supported and conducted in collaboration with Jackson State University (HHSN268201800013I), Tougaloo College (HHSN268201800014I), the Mississippi State Department of Health (HHSN268201800015I), and the University of Mississippi Medical Center (HHSN268201800010I, HHSN268201800011I, and HHSN268201800012I) contracts from the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute for Minority Health and Health Disparities (NIMHD). The authors also wish to thank the staffs and participants of the JHS. This work was also supported by NIH National Heart, Lung, and Blood Institute R01HL117323 (PM). PM receives support through grant 15SFRN2390002 from the American Heart Association. Dr Bress receives support through grant K01HL133468 from the National Heart, Lung, and Blood Institute, Bethesda, MD. Dr Lynn Jorde receives support through grant R35‐GM118335 from the National Institute of General Medical Sciences (NIGMS). Dr Shimbo has received grant support from NHLBI (K24‐HL125704). Dr Jon Van Tassell was support by University of Utah College of Pharmacy for his PharmD Capstone Research Project. Funding Information: Funding information The Jackson Heart Study (JHS) is supported and conducted in collaboration with Jackson State University (HHSN268201800013I), Tougaloo College (HHSN268201800014I), the Mississippi State Department of Health (HHSN268201800015I), and the University of Mississippi Medical Center (HHSN268201800010I, HHSN268201800011I, and HHSN268201800012I) contracts from the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute for Minority Health and Health Disparities (NIMHD). The authors also wish to thank the staffs and participants of the JHS. This work was also supported by NIH National Heart, Lung, and Blood Institute R01HL117323 (PM). PM receives support through grant 15SFRN2390002 from the American Heart Association. Dr Bress receives support through grant K01HL133468 from the National Heart, Lung, and Blood Institute, Bethesda, MD. Dr Lynn Jorde receives support through grant R35-GM118335 from the National Institute of General Medical Sciences (NIGMS). Dr Shimbo has received grant support from NHLBI (K24-HL125704). Dr Jon Van Tassell was support by University of Utah College of Pharmacy for his PharmD Capstone Research Project. The authors thank the Jackson Heart Study team (University of Mississippi Medical Center, Jackson State University, and Tougaloo College) and study participants for their long-term commitment and significant contributions to the study. Publisher Copyright: {\textcopyright} 2020 Wiley Periodicals, Inc.",
year = "2020",
month = feb,
day = "1",
doi = "10.1111/jch.13824",
language = "English (US)",
volume = "22",
pages = "157--166",
journal = "Journal of Clinical Hypertension",
issn = "1524-6175",
publisher = "Wiley-Blackwell",
number = "2",
}