Association of Physical Function and Survival in Older-Adult Renal Transplant Recipients

Amarpali Brar, Angelika Gruessner, Deborah Adey, Fasika Tedla, Ernie Yap, Dheeraj Kaul, Nabil Sumrani, Devon John, Moro O. Salifu

Research output: Contribution to journalArticlepeer-review

Abstract

There is an increase in older-adult renal transplant recipients in United States. The objective of this study was to assess the association between physical function (PF) and patient survival in renal transplant recipients who are aged 65 years or older. Using United Network for Organ Sharing (UNOS) data from 2007 to 2016, renal transplant recipients aged 65 years or older were included. Multivariable Cox regression was used to assess associations between survival and functional status adjusted for age, sex, race, donor quality, diabetes, and dialysis vintage. The study identified 26,721 patients. Patient survival was significantly higher in recipients who needed no assistance and lowest in patients in need of total assistance (P < .0001). In deceased donor (DD) transplants, the relative risk for mortality was 2.06 (1.74-2.43) for total assistance and 1.17 (1.08-1.28) for moderate assistance compared to no assistance (P < .0001). In living donor (LD) transplants, the relative risk of mortality was 1.38 (0.78-2.42) for patients needing total assistance and 1.37 (1.14-1.65) for patients needing moderate assistance compared to patients who did not need assistance (0.003). PF is an independent predictor of post-transplant mortality. Assessment of older potential renal transplant recipients should include assessment and standardization of functional status to counsel about post-transplant survival.

Original languageEnglish (US)
Pages (from-to)913-919
Number of pages7
JournalTransplantation Proceedings
Volume53
Issue number3
DOIs
StatePublished - Apr 2021
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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