Association of HLA antigens and total serum immunoglobulin E level with allergic response and failure to respond to ragweed allergen Ra3

D. G. Marsh; G. A. Chase; L. R. Freidhoff; D. A. Meyers; W. B. Bias

doi:10.1073/pnas.76.6.2903

Association of HLA antigens and total serum immunoglobulin E level with allergic response and failure to respond to ragweed allergen Ra3

D. G. Marsh, G. A. Chase, L. R. Freidhoff, D. A. Meyers, W. B. Bias

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Abstract

We have applied rigorous statistical analysis to human immune response and HLA data in allergic subjects having varying sensitivity to the minor ragweed allergen, Ra3. By using regression analysis on a series of subsets of Ra3 responders and nonresponders, we obtained data supporting the concept of discrete 'responder' and 'nonresponder' phenotypes. We found significant positive associations between Ra3 response and total serum IgE and the presence of HLA antigens of the A2 crossreacting group (A2 and A28), and significant negative associations with antigens of the A3 crossreacting group (A3 and A11). Our results suggest that alleles of the HLA-A locus may function either as immune response or immune suppressor genes or that such alleles are epistatic to the response or suppressor genes. Our data add further support to previous findings that HLA-associated specific IgE response is strongly influenced by genetic regulation of basal IgE level.

Original language	English (US)
Pages (from-to)	2903-2907
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	76
Issue number	6
DOIs	https://doi.org/10.1073/pnas.76.6.2903
State	Published - 1979
Externally published	Yes

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Association of HLA antigens and total serum immunoglobulin E level with allergic response and failure to respond to ragweed allergen Ra3. / Marsh, D. G.; Chase, G. A.; Freidhoff, L. R. et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 76, No. 6, 1979, p. 2903-2907.

Research output: Contribution to journal › Article › peer-review

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Association of HLA antigens and total serum immunoglobulin E level with allergic response and failure to respond to ragweed allergen Ra3

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