Association of genetic ancestry with DNA methylation changes in prostate cancer disparity

Victor Apprey; Songping Wang; Wei Tang; Rick A. Kittles; William M. Southerland; Michael Ittmann; Bernard Kwabi-Addo

doi:10.21873/anticanres.13790

Association of genetic ancestry with DNA methylation changes in prostate cancer disparity

Victor Apprey, Songping Wang, Wei Tang, Rick A. Kittles, William M. Southerland, Michael Ittmann, Bernard Kwabi-Addo

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13 Scopus citations

Abstract

Background: We hypothesized that ancestry-mediated methylated DNA changes may drive racial and ethnic disparity in prostate cancer (PCa). To test this hypothesis, we analyzed genetic ancestry and association with DNA methylation changes in PCa disparity. Materials and Methods: Pyrosequencing and ancestry informative markers were used for DNA methylation and genetic ancestry testing, respectively. Results: Using Spearman rho rank correlation test, the data demonstrated significant (p<0.05) and variable association between African-American ancestry and DNA methylation for all genes investigated in prostate tissues. Conclusion: Genetic ancestry influences DNA methylation and this modifying factor must be considered in epigenetic association studies in populations of admixed patients.

Original language	English (US)
Pages (from-to)	5861-5866
Number of pages	6
Journal	Anticancer research
Volume	39
Issue number	11
DOIs	https://doi.org/10.21873/anticanres.13790
State	Published - 2019

Keywords

AIMs
DNA methylation
Disparity
Prostate cancer

ASJC Scopus subject areas

Oncology
Cancer Research

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10.21873/anticanres.13790

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title = "Association of genetic ancestry with DNA methylation changes in prostate cancer disparity",

abstract = "Background: We hypothesized that ancestry-mediated methylated DNA changes may drive racial and ethnic disparity in prostate cancer (PCa). To test this hypothesis, we analyzed genetic ancestry and association with DNA methylation changes in PCa disparity. Materials and Methods: Pyrosequencing and ancestry informative markers were used for DNA methylation and genetic ancestry testing, respectively. Results: Using Spearman rho rank correlation test, the data demonstrated significant (p<0.05) and variable association between African-American ancestry and DNA methylation for all genes investigated in prostate tissues. Conclusion: Genetic ancestry influences DNA methylation and this modifying factor must be considered in epigenetic association studies in populations of admixed patients.",

keywords = "AIMs, DNA methylation, Disparity, Prostate cancer",

author = "Victor Apprey and Songping Wang and Wei Tang and Kittles, {Rick A.} and Southerland, {William M.} and Michael Ittmann and Bernard Kwabi-Addo",

note = "Funding Information: This work was supported by a grant from Department of Defense Program Idea Award; PC073828 to Bernard Kwabi-Addo and grant 2U54MD007597 from NIMHD, NIH to the RCMI program at Howard University. Publisher Copyright: {\textcopyright} 2019 International Institute of Anticancer Research. All rights reserved.",

year = "2019",

doi = "10.21873/anticanres.13790",

language = "English (US)",

volume = "39",

pages = "5861--5866",

journal = "Anticancer research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "11",

}

TY - JOUR

T1 - Association of genetic ancestry with DNA methylation changes in prostate cancer disparity

AU - Apprey, Victor

AU - Wang, Songping

AU - Tang, Wei

AU - Kittles, Rick A.

AU - Southerland, William M.

AU - Ittmann, Michael

AU - Kwabi-Addo, Bernard

N1 - Funding Information: This work was supported by a grant from Department of Defense Program Idea Award; PC073828 to Bernard Kwabi-Addo and grant 2U54MD007597 from NIMHD, NIH to the RCMI program at Howard University. Publisher Copyright: © 2019 International Institute of Anticancer Research. All rights reserved.

PY - 2019

Y1 - 2019

N2 - Background: We hypothesized that ancestry-mediated methylated DNA changes may drive racial and ethnic disparity in prostate cancer (PCa). To test this hypothesis, we analyzed genetic ancestry and association with DNA methylation changes in PCa disparity. Materials and Methods: Pyrosequencing and ancestry informative markers were used for DNA methylation and genetic ancestry testing, respectively. Results: Using Spearman rho rank correlation test, the data demonstrated significant (p<0.05) and variable association between African-American ancestry and DNA methylation for all genes investigated in prostate tissues. Conclusion: Genetic ancestry influences DNA methylation and this modifying factor must be considered in epigenetic association studies in populations of admixed patients.

AB - Background: We hypothesized that ancestry-mediated methylated DNA changes may drive racial and ethnic disparity in prostate cancer (PCa). To test this hypothesis, we analyzed genetic ancestry and association with DNA methylation changes in PCa disparity. Materials and Methods: Pyrosequencing and ancestry informative markers were used for DNA methylation and genetic ancestry testing, respectively. Results: Using Spearman rho rank correlation test, the data demonstrated significant (p<0.05) and variable association between African-American ancestry and DNA methylation for all genes investigated in prostate tissues. Conclusion: Genetic ancestry influences DNA methylation and this modifying factor must be considered in epigenetic association studies in populations of admixed patients.

KW - AIMs

KW - DNA methylation

KW - Disparity

KW - Prostate cancer

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EP - 5866

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Association of genetic ancestry with DNA methylation changes in prostate cancer disparity

Abstract

Keywords

ASJC Scopus subject areas

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