TY - JOUR
T1 - Association of genetic ancestry with colorectal tumor location in Puerto Rican Latinos
AU - Pérez-Mayoral, Julyann
AU - Soto-Salgado, Marievelisse
AU - Shah, Ebony
AU - Kittles, Rick
AU - Stern, Mariana C.
AU - Olivera, Myrta I.
AU - Gonzalez-Pons, María
AU - Rodriguez-Quilichinni, Segundo
AU - Torres, Marla
AU - Reyes, Jose S.
AU - Tous, Luis
AU - López, Nicolas
AU - Chevere, Victor Carlo
AU - Cruz-Correa, Marcia
N1 - Funding Information:
This work was partially supported by the National Institute on Minority Health and Health Disparities (NIMHD) and the National Institute of Allergy and Infectious Diseases (NIAID) award number MD007587; National Cancer Institute (NCI) award numbers CA130034 and CA096297/CA096300; and the Center for Collaborative Research in Health Disparities RCMI Award Number G12MD007600.
PY - 2019/2/20
Y1 - 2019/2/20
N2 - BACKGROUND: Colorectal cancer (CRC) is the first cause of cancer deaths among Puerto Ricans. The incidence and mortality of CRC in Puerto Rico continue to be on the rise. The burden of CRC in Puerto Rico is higher than among US Hispanics and is second only to African Americans, thus supporting the importance of studying this CRC health disparity. The genetic background of the Puerto Rican population is a mix of European, African, and Amerindian races, which may account, in part, for the differences observed in the CRC mortality rates among Puerto Ricans. The objective of the study was to assess the role of genetic ancestry in CRC risk and its association with clinicopathological features of CRC tumors in Puerto Ricans. RESULTS: We used a validated panel of 105 ancestry informative markers (AIMs) to estimate genetic ancestry in 406 Puerto Rican CRC cases and 425 Puerto Rican controls. We examined the association of genetic ancestry with CRC risk and tumor clinicopathological characteristics. CONCLUSIONS: The mean ancestry proportions in the study population were 61% European, 21% African, and 18% Amerindian. No association was observed between genetic ancestry and risk of CRC. However, African ancestry was associated with an increased risk of developing rectal tumors (OR = 1.55, 95% CI 1.04-2.31). Additional studies are needed to fully elucidate the role of African ancestry in CRC carcinogenesis.
AB - BACKGROUND: Colorectal cancer (CRC) is the first cause of cancer deaths among Puerto Ricans. The incidence and mortality of CRC in Puerto Rico continue to be on the rise. The burden of CRC in Puerto Rico is higher than among US Hispanics and is second only to African Americans, thus supporting the importance of studying this CRC health disparity. The genetic background of the Puerto Rican population is a mix of European, African, and Amerindian races, which may account, in part, for the differences observed in the CRC mortality rates among Puerto Ricans. The objective of the study was to assess the role of genetic ancestry in CRC risk and its association with clinicopathological features of CRC tumors in Puerto Ricans. RESULTS: We used a validated panel of 105 ancestry informative markers (AIMs) to estimate genetic ancestry in 406 Puerto Rican CRC cases and 425 Puerto Rican controls. We examined the association of genetic ancestry with CRC risk and tumor clinicopathological characteristics. CONCLUSIONS: The mean ancestry proportions in the study population were 61% European, 21% African, and 18% Amerindian. No association was observed between genetic ancestry and risk of CRC. However, African ancestry was associated with an increased risk of developing rectal tumors (OR = 1.55, 95% CI 1.04-2.31). Additional studies are needed to fully elucidate the role of African ancestry in CRC carcinogenesis.
KW - African ancestry
KW - Colorectal cancer
KW - Colorectal tumors
KW - Genetic ancestry
KW - Hispanic
KW - Latinos
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U2 - 10.1186/s40246-019-0196-4
DO - 10.1186/s40246-019-0196-4
M3 - Article
C2 - 30786938
AN - SCOPUS:85061973295
SN - 1473-9542
VL - 13
SP - 12
JO - Human genomics
JF - Human genomics
IS - 1
ER -