Association of cytokine gene polymorphisms with rate of decline in lung function

Berran Yucesoy, Margaret Kurzius-Spencer, Victor J. Johnson, Kara Fluharty, Michael L. Kashon, Stefano Guerra, Michael I. Luster, Jefferey L. Burgess

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


OBJECTIVE: To investigate whether genetic variants involved in cytokine expression are associated with the age-related rate of decline in forced expiratory volume in 1 second (FEV1). METHODS: Functional polymorphisms in the TNFα, TGFβ1, IL-1β, IL-1RN, IL-13, and IL-8 genes were investigated in 374 active firefighters with at least five pulmonary function tests. RESULTS: A protective effect was found between the presence of the TGFβ1 -509 TT genotype and rate of decline in FEV1 (P = 0.043). Carrying an A allele at TNFα -308 (P = 0.010) and GG genotype at TNFα -238 (P = 0.028) was associated with a more rapid rate of FEV1 decline. The TNFα -308A/-238G haplotype was also associated with an increased rate of decline as compared with the other haplotypes. CONCLUSIONS: Interindividual variability in progressive decline in FEV1 may be explained in part by genetic variations within genes involved in inflammatory responses.

Original languageEnglish (US)
Pages (from-to)642-648
Number of pages7
JournalJournal of occupational and environmental medicine
Issue number6
StatePublished - Jun 2008

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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