TY - JOUR
T1 - Association of cytokine gene polymorphisms with rate of decline in lung function
AU - Yucesoy, Berran
AU - Kurzius-Spencer, Margaret
AU - Johnson, Victor J.
AU - Fluharty, Kara
AU - Kashon, Michael L.
AU - Guerra, Stefano
AU - Luster, Michael I.
AU - Burgess, Jefferey L.
PY - 2008/6
Y1 - 2008/6
N2 - OBJECTIVE: To investigate whether genetic variants involved in cytokine expression are associated with the age-related rate of decline in forced expiratory volume in 1 second (FEV1). METHODS: Functional polymorphisms in the TNFα, TGFβ1, IL-1β, IL-1RN, IL-13, and IL-8 genes were investigated in 374 active firefighters with at least five pulmonary function tests. RESULTS: A protective effect was found between the presence of the TGFβ1 -509 TT genotype and rate of decline in FEV1 (P = 0.043). Carrying an A allele at TNFα -308 (P = 0.010) and GG genotype at TNFα -238 (P = 0.028) was associated with a more rapid rate of FEV1 decline. The TNFα -308A/-238G haplotype was also associated with an increased rate of decline as compared with the other haplotypes. CONCLUSIONS: Interindividual variability in progressive decline in FEV1 may be explained in part by genetic variations within genes involved in inflammatory responses.
AB - OBJECTIVE: To investigate whether genetic variants involved in cytokine expression are associated with the age-related rate of decline in forced expiratory volume in 1 second (FEV1). METHODS: Functional polymorphisms in the TNFα, TGFβ1, IL-1β, IL-1RN, IL-13, and IL-8 genes were investigated in 374 active firefighters with at least five pulmonary function tests. RESULTS: A protective effect was found between the presence of the TGFβ1 -509 TT genotype and rate of decline in FEV1 (P = 0.043). Carrying an A allele at TNFα -308 (P = 0.010) and GG genotype at TNFα -238 (P = 0.028) was associated with a more rapid rate of FEV1 decline. The TNFα -308A/-238G haplotype was also associated with an increased rate of decline as compared with the other haplotypes. CONCLUSIONS: Interindividual variability in progressive decline in FEV1 may be explained in part by genetic variations within genes involved in inflammatory responses.
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U2 - 10.1097/JOM.0b013e31816515e1
DO - 10.1097/JOM.0b013e31816515e1
M3 - Article
C2 - 18545091
AN - SCOPUS:58949083626
SN - 1076-2752
VL - 50
SP - 642
EP - 648
JO - Journal of occupational and environmental medicine
JF - Journal of occupational and environmental medicine
IS - 6
ER -