TY - JOUR
T1 - Association of children’s urinary CC16 levels with arsenic concentrations in multiple environmental media
AU - Beamer, Paloma I.
AU - Klimecki, Walter T.
AU - Loh, Miranda
AU - Van Horne, Yoshira Ornelas
AU - Sugeng, Anastasia J.
AU - Lothrop, Nathan
AU - Billheimer, Dean
AU - Guerra, Stefano
AU - Lantz, Robert Clark
AU - Canales, Robert A.
AU - Martinez, Fernando D.
N1 - Publisher Copyright:
© 2016 by the authors; licensee MDPI, Basel, Switzerland.
PY - 2016/5/23
Y1 - 2016/5/23
N2 - Arsenic exposure has been associated with decreased club cell secretory protein (CC16) levels in adults. Further, both arsenic exposure and decreased levels of CC16 in childhood have been associated with decreased adult lung function. Our objective was to determine if urinary CC16 levels in children are associated with arsenic concentrations in environmental media collected from their homes. Yard soil, house dust, and tap water were taken from 34 homes. Urine and toenail samples were collected from 68 children. All concentrations were natural log-transformed prior to data analysis. There were associations between urinary CC16 and arsenic concentration in soil (b = -0.43, p = 0.001, R2 = 0.08), water (b = -0.22, p = 0.07, R2 = 0.03), house dust (b = -0.37, p = 0.07, R2 = 0.04), and dust loading (b = -0.21, p = 0.04, R2 = 0.04). In multiple analyses, only the concentration of arsenic in soil was associated with urinary CC16 levels (b = -0.42, p = 0.02, R2 = 0.14 (full model)) after accounting for other factors. The association between urinary CC16 and soil arsenic may suggest that localized arsenic exposure in the lungs could damage the airway epithelium and predispose children for diminished lung function. Future work to assess this possible mechanism should examine potential associations between airborne arsenic exposures, CC16 levels, lung function, and other possible confounders in children in arsenic-impacted communities.
AB - Arsenic exposure has been associated with decreased club cell secretory protein (CC16) levels in adults. Further, both arsenic exposure and decreased levels of CC16 in childhood have been associated with decreased adult lung function. Our objective was to determine if urinary CC16 levels in children are associated with arsenic concentrations in environmental media collected from their homes. Yard soil, house dust, and tap water were taken from 34 homes. Urine and toenail samples were collected from 68 children. All concentrations were natural log-transformed prior to data analysis. There were associations between urinary CC16 and arsenic concentration in soil (b = -0.43, p = 0.001, R2 = 0.08), water (b = -0.22, p = 0.07, R2 = 0.03), house dust (b = -0.37, p = 0.07, R2 = 0.04), and dust loading (b = -0.21, p = 0.04, R2 = 0.04). In multiple analyses, only the concentration of arsenic in soil was associated with urinary CC16 levels (b = -0.42, p = 0.02, R2 = 0.14 (full model)) after accounting for other factors. The association between urinary CC16 and soil arsenic may suggest that localized arsenic exposure in the lungs could damage the airway epithelium and predispose children for diminished lung function. Future work to assess this possible mechanism should examine potential associations between airborne arsenic exposures, CC16 levels, lung function, and other possible confounders in children in arsenic-impacted communities.
KW - Arsenic
KW - CC16
KW - Children
KW - Drinking water
KW - Multi-route exposure assessment
KW - Respiratory health
KW - Soil
KW - Uteroglobulin
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U2 - 10.3390/ijerph13050521
DO - 10.3390/ijerph13050521
M3 - Article
C2 - 27223295
AN - SCOPUS:84969856771
SN - 1661-7827
VL - 13
JO - International journal of environmental research and public health
JF - International journal of environmental research and public health
IS - 5
M1 - 521
ER -