Abstract
Goal: The goal of this study was to correlate upright and prone bolus transit time (BTT) on barium esophagography (BE) with esophageal peristalsis on high-resolution manometry (HRM) and self-reported dysphagia in patients with normal lower esophageal sphincter parameters on HRM. Background: BTT on BE could be the gold standard for assessing the effectiveness of esophageal peristalsis if it can be quantified. Materials and Methods: Patients with normal lower esophageal sphincter parameters and standard-protocol BE from 2017 to 2020 were included. Patients were divided, based on the number of normal swallows (distal contractile integral >450 mm Hg-s-cm), into 11 groups (10 normal swallows to 0 normal swallows). Liquid barium swallows in prone position were objectively evaluated for prone BTT. Patients reported difficulty in swallowing on a scale from 0 (none) to 4 (very severe). Fractional polynomial and logistic regression analysis were used to study the association (along with the rate of change) between BTT, peristalsis, and dysphagia. Results: A total of 146 patients were included. Prone BTT increased as the number of normal swallows decreased (P<0.001). Two deflection points were noted on the association between peristalsis and prone BTT at 50% normal swallows, 40 seconds and 30% normal swallows, 80 seconds, after which peristaltic function declined independently of prone BTT. Patients with prone BTT>40 seconds had nearly 6-fold higher odds of 0% normal swallows on HRM than patients with prone BTT<40 seconds (P=0.002). Increasing prone BTT was associated with increasing dysphagia grades 1 and 2 (P≤0.036). Conclusions: Esophageal motility can be quantified by BE. Prone BTT correlates with the proportion of normal esophageal swallows and dysphagia.
Original language | English (US) |
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Pages (from-to) | 748-755 |
Number of pages | 8 |
Journal | Journal of clinical gastroenterology |
Volume | 56 |
Issue number | 9 |
DOIs | |
State | Published - Oct 1 2022 |
Keywords
- barium esophagram
- bolus transit time
- dysphagia
- esophageal peristalsis
- high-resolution manometry
ASJC Scopus subject areas
- Gastroenterology