TY - JOUR
T1 - Association between PTPN1 polymorphisms and obesity-related phenotypes in European adolescents
T2 - influence of physical activity
AU - Salazar-Tortosa, Diego F.
AU - Labayen, Idoia
AU - González-Gross, Marcela
AU - Seral-Cortes, Miguel
AU - Moreno, Luis A.
AU - G. Zapico, Augusto
AU - Widhalm, Kurt
AU - Meirhaeghe, Aline
AU - Enard, David
AU - R. Ruiz, Jonatan
N1 - Funding Information:
The HELENA Study was supported by contract FOOD-CT-2005-007034 from the European Community Sixth RTD Framework Programme. The present study was also supported by a Marie S. Curie Global Fellowship within the European Union research and innovation framework programme (2014–2020; ClimAHealth; https://doi.org/10.3030/101030971 ), by a grant from the Spanish Ministry of Science and Innovation (AGL2007-29784-E), by Redes Temáticas de Investigación Cooperativa RETIC grant (Red SAMID RD16/0022), by the University of Granada Plan Propio de Investigación (Excellence actions: Unit of Excellence on Exercise and Health [UCEES]), by the Junta de Andalucía, Consejería de Economía, Conocimiento, Empresas y Universidad (refs. P18–624 RT-4455, SOMM17/6107/UGR), and by grants from the Public University of Navarra, “Ayudas a Grupos de Investigación (2019)”. The content of this article reflects only the authors’ views, and the European Community is not liable for any use that may be made of the information contained therein.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.
PY - 2022
Y1 - 2022
N2 - Background: To study the associations of Protein Tyrosine Phosphatase-N1 (PTPN1) polymorphisms with obesity-related phenotypes in European adolescents, and the influence of physical activity on these relationships. Methods: Five polymorphisms of PTPN1 were genotyped in 1057 European adolescents (12–18 years old). We measured several phenotypes related to obesity, such as adiposity markers, and biochemical and clinical parameters. Physical activity was objectively measured by accelerometry. Results: The T, A, T, T and G alleles of the rs6067472, rs10485614, rs2143511, rs6020608 and rs968701 polymorphisms, respectively, were associated with lower levels of obesity-related phenotypes (i.e., body mass index, body fat percentage, hip circumference, fat mass index, systolic blood pressure and leptin) in European adolescents. In addition, the TATTG haplotype was associated with lower body fat percentage and fat mass index compared to the AACCA haplotype. Finally, when physical activity levels were considered, alleles of the rs6067472, rs2143511, rs6020608 and rs968701 polymorphisms were only associated with lower adiposity in active adolescents. Conclusions: PTPN1 polymorphisms were associated with adiposity in European adolescents. Specifically, alleles of these polymorphisms were associated with lower adiposity only in physically active adolescents. Therefore, meeting the recommendations of daily physical activity may reduce obesity risk by modulating the genetic predisposition to obesity. Impact: Using gene-phenotype and gene*environment analyses, we detected associations between polymorphisms of the Protein Tyrosine Phosphatase-N1 (PTPN1) gene and obesity-related phenotypes, suggesting a mechanism that can be modulated by physical activity.This study shows that genetic variability of PTPN1 is associated with adiposity, while physical activity seems to modulate the genetic predisposition.This brings insights about the mechanisms by which physical activity positively influences obesity.
AB - Background: To study the associations of Protein Tyrosine Phosphatase-N1 (PTPN1) polymorphisms with obesity-related phenotypes in European adolescents, and the influence of physical activity on these relationships. Methods: Five polymorphisms of PTPN1 were genotyped in 1057 European adolescents (12–18 years old). We measured several phenotypes related to obesity, such as adiposity markers, and biochemical and clinical parameters. Physical activity was objectively measured by accelerometry. Results: The T, A, T, T and G alleles of the rs6067472, rs10485614, rs2143511, rs6020608 and rs968701 polymorphisms, respectively, were associated with lower levels of obesity-related phenotypes (i.e., body mass index, body fat percentage, hip circumference, fat mass index, systolic blood pressure and leptin) in European adolescents. In addition, the TATTG haplotype was associated with lower body fat percentage and fat mass index compared to the AACCA haplotype. Finally, when physical activity levels were considered, alleles of the rs6067472, rs2143511, rs6020608 and rs968701 polymorphisms were only associated with lower adiposity in active adolescents. Conclusions: PTPN1 polymorphisms were associated with adiposity in European adolescents. Specifically, alleles of these polymorphisms were associated with lower adiposity only in physically active adolescents. Therefore, meeting the recommendations of daily physical activity may reduce obesity risk by modulating the genetic predisposition to obesity. Impact: Using gene-phenotype and gene*environment analyses, we detected associations between polymorphisms of the Protein Tyrosine Phosphatase-N1 (PTPN1) gene and obesity-related phenotypes, suggesting a mechanism that can be modulated by physical activity.This study shows that genetic variability of PTPN1 is associated with adiposity, while physical activity seems to modulate the genetic predisposition.This brings insights about the mechanisms by which physical activity positively influences obesity.
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U2 - 10.1038/s41390-022-02377-1
DO - 10.1038/s41390-022-02377-1
M3 - Article
AN - SCOPUS:85141708176
JO - Pediatric Research
JF - Pediatric Research
SN - 0031-3998
ER -