Association between exposure to ambient air particulates and metabolic syndrome components in a Saudi Arabian population

Magdy Shamy; Mansour Alghamdi; Mamdouh I. Khoder; Abdullah M. Mohorjy; Alser A. Alkhatim; Abdulrahman K. Alkhalaf; Jason Brocato; Lung Chi Chen; George D. Thurston; Chris C. Lim; Max Costa

doi:10.3390/ijerph15010027

Association between exposure to ambient air particulates and metabolic syndrome components in a Saudi Arabian population

Magdy Shamy, Mansour Alghamdi, Mamdouh I. Khoder, Abdullah M. Mohorjy, Alser A. Alkhatim, Abdulrahman K. Alkhalaf, Jason Brocato, Lung Chi Chen, George D. Thurston, Chris C. Lim, Max Costa

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Recent epidemiological evidence suggests that exposure to particulates may be a factor in the etiology of metabolic syndrome (MetS). In this novel study, we investigated the relationship between particulate levels and prevalence of MetS component abnormalities (hypertension, hyperglycemia, obesity) in a recruited cohort (N = 2025) in Jeddah, Saudi Arabia. We observed significant associations between a 10 µg/m³ increase in PM_2.5 and increased risks for MetS (Risk Ratio (RR): 1.12; 95% Confidence Interval (CI): 1.06–1.19), hyperglycemia (RR: 1.08; 95% CI: 1.03–1.14), and hypertension (RR: 1.09; 95% CI: 1.04–1.14). PM_2.5 from soil/road dust was found to be associated with hyperglycemia (RR: 1.12; 95% CI: 1.06–1.19) and hypertension (RR: 1.11; 95% CI: 1.05–1.18), while PM_2.5 from traffic was associated with hyperglycemia (RR: 1.33; 95% CI: 1.05–1.71). We did not observe any health associations with source-specific mass exposures. Our findings suggest that exposure to specific elemental components of PM_2.5, especially Ni, may contribute to the development of cardiometabolic disorders.

Original language	English (US)
Article number	27
Journal	International journal of environmental research and public health
Volume	15
Issue number	1
DOIs	https://doi.org/10.3390/ijerph15010027
State	Published - Jan 2018
Externally published	Yes

Keywords

Air pollution
Diabetes
Hyperglycemi
Hypertension
Metabolic syndrome
Particulate matter

ASJC Scopus subject areas

Pollution
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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10.3390/ijerph15010027

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Shamy, M., Alghamdi, M., Khoder, M. I., Mohorjy, A. M., Alkhatim, A. A., Alkhalaf, A. K., Brocato, J., Chen, L. C., Thurston, G. D., Lim, C. C., & Costa, M. (2018). Association between exposure to ambient air particulates and metabolic syndrome components in a Saudi Arabian population. International journal of environmental research and public health, 15(1), Article 27. https://doi.org/10.3390/ijerph15010027

Shamy, M, Alghamdi, M, Khoder, MI, Mohorjy, AM, Alkhatim, AA, Alkhalaf, AK, Brocato, J, Chen, LC, Thurston, GD, Lim, CC & Costa, M 2018, 'Association between exposure to ambient air particulates and metabolic syndrome components in a Saudi Arabian population', International journal of environmental research and public health, vol. 15, no. 1, 27. https://doi.org/10.3390/ijerph15010027

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title = "Association between exposure to ambient air particulates and metabolic syndrome components in a Saudi Arabian population",

abstract = "Recent epidemiological evidence suggests that exposure to particulates may be a factor in the etiology of metabolic syndrome (MetS). In this novel study, we investigated the relationship between particulate levels and prevalence of MetS component abnormalities (hypertension, hyperglycemia, obesity) in a recruited cohort (N = 2025) in Jeddah, Saudi Arabia. We observed significant associations between a 10 µg/m3 increase in PM2.5 and increased risks for MetS (Risk Ratio (RR): 1.12; 95% Confidence Interval (CI): 1.06–1.19), hyperglycemia (RR: 1.08; 95% CI: 1.03–1.14), and hypertension (RR: 1.09; 95% CI: 1.04–1.14). PM2.5 from soil/road dust was found to be associated with hyperglycemia (RR: 1.12; 95% CI: 1.06–1.19) and hypertension (RR: 1.11; 95% CI: 1.05–1.18), while PM2.5 from traffic was associated with hyperglycemia (RR: 1.33; 95% CI: 1.05–1.71). We did not observe any health associations with source-specific mass exposures. Our findings suggest that exposure to specific elemental components of PM2.5, especially Ni, may contribute to the development of cardiometabolic disorders.",

keywords = "Air pollution, Diabetes, Hyperglycemi, Hypertension, Metabolic syndrome, Particulate matter",

author = "Magdy Shamy and Mansour Alghamdi and Khoder, {Mamdouh I.} and Mohorjy, {Abdullah M.} and Alkhatim, {Alser A.} and Alkhalaf, {Abdulrahman K.} and Jason Brocato and Chen, {Lung Chi} and Thurston, {George D.} and Lim, {Chris C.} and Max Costa",

note = "Funding Information: Acknowledgments: This study was funded by King Abdulaziz University (KAU), Jeddah, under grant 4/00/00/252 and by NIEHS grant under P30ES000260. The sponsors did not have any role in the study design. Publisher Copyright: {\textcopyright} 2017 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2018",

month = jan,

doi = "10.3390/ijerph15010027",

language = "English (US)",

volume = "15",

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AU - Shamy, Magdy

AU - Alghamdi, Mansour

AU - Khoder, Mamdouh I.

AU - Mohorjy, Abdullah M.

AU - Alkhatim, Alser A.

AU - Alkhalaf, Abdulrahman K.

AU - Brocato, Jason

AU - Chen, Lung Chi

AU - Thurston, George D.

AU - Lim, Chris C.

AU - Costa, Max

N1 - Funding Information: Acknowledgments: This study was funded by King Abdulaziz University (KAU), Jeddah, under grant 4/00/00/252 and by NIEHS grant under P30ES000260. The sponsors did not have any role in the study design. Publisher Copyright: © 2017 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2018/1

Y1 - 2018/1

N2 - Recent epidemiological evidence suggests that exposure to particulates may be a factor in the etiology of metabolic syndrome (MetS). In this novel study, we investigated the relationship between particulate levels and prevalence of MetS component abnormalities (hypertension, hyperglycemia, obesity) in a recruited cohort (N = 2025) in Jeddah, Saudi Arabia. We observed significant associations between a 10 µg/m3 increase in PM2.5 and increased risks for MetS (Risk Ratio (RR): 1.12; 95% Confidence Interval (CI): 1.06–1.19), hyperglycemia (RR: 1.08; 95% CI: 1.03–1.14), and hypertension (RR: 1.09; 95% CI: 1.04–1.14). PM2.5 from soil/road dust was found to be associated with hyperglycemia (RR: 1.12; 95% CI: 1.06–1.19) and hypertension (RR: 1.11; 95% CI: 1.05–1.18), while PM2.5 from traffic was associated with hyperglycemia (RR: 1.33; 95% CI: 1.05–1.71). We did not observe any health associations with source-specific mass exposures. Our findings suggest that exposure to specific elemental components of PM2.5, especially Ni, may contribute to the development of cardiometabolic disorders.

AB - Recent epidemiological evidence suggests that exposure to particulates may be a factor in the etiology of metabolic syndrome (MetS). In this novel study, we investigated the relationship between particulate levels and prevalence of MetS component abnormalities (hypertension, hyperglycemia, obesity) in a recruited cohort (N = 2025) in Jeddah, Saudi Arabia. We observed significant associations between a 10 µg/m3 increase in PM2.5 and increased risks for MetS (Risk Ratio (RR): 1.12; 95% Confidence Interval (CI): 1.06–1.19), hyperglycemia (RR: 1.08; 95% CI: 1.03–1.14), and hypertension (RR: 1.09; 95% CI: 1.04–1.14). PM2.5 from soil/road dust was found to be associated with hyperglycemia (RR: 1.12; 95% CI: 1.06–1.19) and hypertension (RR: 1.11; 95% CI: 1.05–1.18), while PM2.5 from traffic was associated with hyperglycemia (RR: 1.33; 95% CI: 1.05–1.71). We did not observe any health associations with source-specific mass exposures. Our findings suggest that exposure to specific elemental components of PM2.5, especially Ni, may contribute to the development of cardiometabolic disorders.

KW - Air pollution

KW - Diabetes

KW - Hyperglycemi

KW - Hypertension

KW - Metabolic syndrome

KW - Particulate matter

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JF - International journal of environmental research and public health

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ER -

Association between exposure to ambient air particulates and metabolic syndrome components in a Saudi Arabian population

Abstract

Keywords

ASJC Scopus subject areas

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