Assisted ventilation during 'bystander' CPR in a swine acute myocardial infarction model does not improve outcome

Robert A. Berg, Karl B. Kern, Ronald W. Hilwig, Gordon A. Ewy

Research output: Contribution to journalArticlepeer-review

144 Scopus citations


Background: Mouth-to-mouth rescue breathing is a barrier to the performance of bystander cardiopulmonary resuscitation (CPR). We evaluated the need for assisted ventilation during simulated single-rescuer bystander CPR in a swine myocardial infarction model of prehospital cardiac arrest. Methods and Results: Steel cylinders were placed in the mid left anterior descending coronary arteries of 43 swine. Two minutes after ventricular fibrillation, animals were randomly assigned to 10 minutes of hand-bag-valve ventilation with 17% oxygen and 4% carbon dioxide plus chest compressions (CC+V), chest compressions only (CC), or no CPR (control group). Standard advanced life support was then provided. Animals successfully resuscitated received 1 hour of intensive care support and were observed for 24 hours. Five of 14 CC animals, 3 of 15 CC+V animals, and 1 of 14 controls survived for 24 hours (CC versus controls, P=.07). Myocardial oxygen delivery and consumption were greater among surviving animals than nonsurvivors but did not differ between CC and CC+V animals. Conclusions: In this acute myocardial infarction model of prehospital single-rescuer bystander CPR, assisted ventilation did not improve outcome.

Original languageEnglish (US)
Pages (from-to)4364-4371
Number of pages8
Issue number12
StatePublished - 1997


  • Cardiopulmonary resuscitation
  • Heart arrest
  • Myocardial blood flow
  • Pulmonary ventilation
  • Survival
  • Ventilation
  • Ventricular fibrillation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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