Assisted ventilation does not improve outcome in a porcine model of single-rescuer bystander cardiopulmonary resuscitation

Robert A. Berg, Karl B. Kern, Ronald W. Hilwig, Marc D. Berg, Arthur B. Sanders, Charles W. Otto, Gordon A. Ewy

Research output: Contribution to journalArticlepeer-review

205 Scopus citations


Background: Mouth-to-mouth rescue breathing is a barrier to the performance of bystander cardiopulmonary resuscitation (CPR). We evaluated the need for assisted ventilation during simulated single-rescuer bystander CPR in a swine model of prehospital cardiac arrest. Methods and Results: Five minutes after ventricular fibrillation, swine were randomly assigned to 8 minutes of hand-bag-valve ventilation with 17% oxygen and 4% carbon dioxide plus chest compressions (CC+V), chest compressions only (CC), or no CPR (control group). Standard advanced life support was then provided. Animals successfully resuscitated received 1 hour of intensive care support and were observed for 24 hours. All 10 CC animals, 9 of the 10 CC+V animals, and 4 of the 6 control animals attained return of spontaneous circulation. Five of the 10 CC animals, 6 of the 10 CC+V animals, and none of the 6 control animals survived for 24 hours (CC versus controls, P=.058; CC+ V versus controls, P<.03). All 24-hour survivors were normal or nearly normal neurologically. Conclusions: In this model of prehospital single-rescuer bystander CPR, successful initial resuscitation, 24-hour survival, and neurological outcome were similar after chest compressions only or chest compressions plus assisted ventilation. Both techniques tended to improve outcome compared with no bystander CPR.

Original languageEnglish (US)
Pages (from-to)1635-1641
Number of pages7
Issue number6
StatePublished - 1997


  • cardiopulmonary resuscitation
  • fibrillation
  • heart arrest
  • survival
  • ventilation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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