@article{eba98d82eb184a04b91ff6698330ed85,
title = "Assisted reproductive technology or infertility: What underlies adverse outcomes? Lessons from the Massachusetts Outcome Study of Assisted Reproductive Technology",
abstract = "Assisted reproductive technology (ART, defined here as including only in vitro fertilization and related technologies) is associated with increased adverse pregnancy, neonatal, and childhood developmental outcomes, even in singletons. The comparison group for many of these studies has often been a fertile population that conceived without assistance. The Massachusetts Outcome Study of Assisted Reproductive Technology (MOSART) was initiated to define a subfertile population with which to compare ART outcomes. Over >10 years, we have used the MOSART database to not only study pregnancy abnormalities and delivery complications but also evaluate ongoing health of women, infants, and children. This article will review studies from the MOSART in the context of how they compare with those of other investigations. We will present MOSART studies that identified the influence of ART and subfertility/infertility on adverse pregnancy (pregnancy hypertensive disorder, gestational diabetes, and placental abnormality) and delivery (preterm birth and low birth weight) outcomes as well as on maternal and child hospitalizations. We will provide evidence that although subfertility/infertility increases the risk of adverse outcomes, there is additional risk associated with the use of ART. Studies exploring the contribution of placental abnormalities as a factor adding to this increased ART-associated risk will be described.",
keywords = "Assisted reproductive technology (ART), child health, maternal health, placental abnormalities, preterm birth",
author = "Stern, {Judy E.} and Farland, {Leslie V.} and Hwang, {Sunah S.} and Dmitry Dukhovny and Coddington, {Charles C.} and Cabral, {Howard J.} and Missmer, {Stacey A.} and Eugene Declercq and Hafsatou Diop",
note = "Funding Information: J.E.S. reports funding from NIH ( HD67270 and HD064595 ) for the submitted work. L.V.F. reports funding from R01 HD67270 for the submitted work and travel support from the Pacific Coast Reproductive Society . S.S.H. has nothing to disclose. D.D. reports funding from the National Institutes of Health for the submitted work. C.C.C. is an Adjunct Board Member for PCRS (unpaid). H.J.C. reports NIH grant for the current project. S.A.M. reports funding from NIH ( HD67270 ) for the submitted work; grants from AbbVie , NIH , and Marriot Family Foundation outside the submitted work; honoraria from University British Columbia and WERF; travel support from the International Federation of Fertility Societies (IFFS) World Congress, ESHRE 2019 (and 2020 virtual), International Association for the Study of Pain (IASP) 4th World Congress on Abdominal and Pelvic Pain (WCAPP) 2019, National Endometriosis Network UK Meeting 2019, Society for Reproductive Investigation – 69th Annual Scientific Meeting (2022); personal fees from AbbVie, Roche, and Frontiers in Reproductive Health; and unpaid leadership roles in SWHR, WERF, WES, ASRM, and ESHRE. E.D. reports funding from NIH R01 HD064595-01 and R01HD067270 for the submitted work. H.D. reports funding from NIH 67270 and 64595. Funding Information: Supported by NIH grants HD67270 and HD064595 . Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2022",
month = oct,
doi = "10.1016/j.xfnr.2022.06.003",
language = "English (US)",
volume = "3",
pages = "242--255",
journal = "F and S Reviews",
issn = "2666-5719",
publisher = "Elsevier Inc.",
number = "4",
}