Assessment of revascularization impact on microvascular oxygenation and perfusion using spatial frequency domain imaging

Ikeoluwapo K. Bolakale-Rufai, Mallory R. Thompson, Kirsten Concha-Moore, Samuel Jett, Shubhangi Awasthi, David J. Cuccia, Amaan Mazhar, Craig C. Weinkauf

Research output: Contribution to journalArticlepeer-review

Abstract

The microvasculature (with vessels <100 μm in diameter) plays a crucial role in tissue oxygenation, perfusion and wound healing in the lower limb. While this holds clinical significance, microvasculature evaluation in the limbs is not a standard practice. Surgical interventions focus on reestablishing blood flow in larger vessels affected by the peripheral artery disease (PAD). Nevertheless, the impact of revascularization on tissue oxygenation and perfusion in severe microvascular disease (MVD) is still unknown. We present the cases of two patients who underwent surgical revascularization for peripheral blood flow with different outcomes. Patient A had PAD, while B had PAD, severe MVD and a non-healing wound. Although both showed improvements in ankle-brachial index post-op, spatial frequency domain imaging metrics (which measure microvascular oxygenation and perfusion) remained unchanged in B, indicating a potential gap in assessing the surgical efficacy in MVD using ankle brachial index and emphasizing microcirculation evaluation in optimizing wound healing outcomes.

Original languageEnglish (US)
Article numberrjad382
JournalJournal of Surgical Case Reports
Volume2023
Issue number7
DOIs
StatePublished - Jul 1 2023

Keywords

  • SFDI
  • microvascular disease
  • revascularization

ASJC Scopus subject areas

  • Surgery

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