TY - JOUR
T1 - Assessment of neuroplasticity in late-life depression with transcranial magnetic stimulation
AU - Bhandari, Apoorva
AU - Lissemore, Jennifer I.
AU - Rajji, Tarek K.
AU - Mulsant, Benoit H.
AU - Cash, Robin F.H.
AU - Noda, Yoshihiro
AU - Zomorrodi, Reza
AU - Karp, Jordan F.
AU - Lenze, Eric J.
AU - Reynolds, Charles F.
AU - Daskalakis, Zafiris J.
AU - Blumberger, Daniel M.
N1 - Publisher Copyright:
© 2018
PY - 2018/10
Y1 - 2018/10
N2 - Background: Studies using Transcranial Magnetic Stimulation (TMS), a non-invasive method of brain stimulation, have implicated impaired neuroplasticity in the pathophysiology of depression in younger adults. The role of neuroplasticity in late-life depression (LLD) has not yet been explored using TMS. Objective: This study aimed at evaluating motor cortical neuroplasticity using paired associative stimulation (PAS). Single-pulse TMS was used to induce motor-evoked potentials (MEP) in the contralateral hand muscle before and after PAS. The potentiation of MEP amplitudes after PAS was used as an indirect index of associative plasticity and long-term potentiation (LTP) (i.e. PAS-LTP). Results: 48 older adults with depression and 34 age-matched healthy controls (HC) were compared. PAS- LTP was successfully induced in 68.8% of older adults with depression and 47.1% of HC. At the group level, older adults with depression failed to show statistically significant induction of neuroplasticity, which was observed in HC. However, no significant differences were observed between the two groups for PAS-LTP. Conclusion: Our results suggest that associative plasticity does not differ substantially between older adults with depression and age-matched HC. Continued research is needed to more comprehensively understand the role of neuroplasticity in the pathophysiology of LLD.
AB - Background: Studies using Transcranial Magnetic Stimulation (TMS), a non-invasive method of brain stimulation, have implicated impaired neuroplasticity in the pathophysiology of depression in younger adults. The role of neuroplasticity in late-life depression (LLD) has not yet been explored using TMS. Objective: This study aimed at evaluating motor cortical neuroplasticity using paired associative stimulation (PAS). Single-pulse TMS was used to induce motor-evoked potentials (MEP) in the contralateral hand muscle before and after PAS. The potentiation of MEP amplitudes after PAS was used as an indirect index of associative plasticity and long-term potentiation (LTP) (i.e. PAS-LTP). Results: 48 older adults with depression and 34 age-matched healthy controls (HC) were compared. PAS- LTP was successfully induced in 68.8% of older adults with depression and 47.1% of HC. At the group level, older adults with depression failed to show statistically significant induction of neuroplasticity, which was observed in HC. However, no significant differences were observed between the two groups for PAS-LTP. Conclusion: Our results suggest that associative plasticity does not differ substantially between older adults with depression and age-matched HC. Continued research is needed to more comprehensively understand the role of neuroplasticity in the pathophysiology of LLD.
KW - Aging
KW - Late-life depression
KW - Long-term potentiation
KW - N-Methyl-D-Aspartate
KW - Neuroplasticity
KW - Paired associative stimulation
KW - Transcranial magnetic stimulation
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U2 - 10.1016/j.jpsychires.2018.08.022
DO - 10.1016/j.jpsychires.2018.08.022
M3 - Article
C2 - 30195122
AN - SCOPUS:85053158045
SN - 0022-3956
VL - 105
SP - 63
EP - 70
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
ER -