TY - JOUR
T1 - Assessment of antioxidant and antidiabetic properties of Agaricus blazei Murill extracts
AU - Wei, Qi
AU - Zhan, Yishu
AU - Chen, Bingzhi
AU - Xie, Baogui
AU - Fang, Ting
AU - Ravishankar, Sadhana
AU - Jiang, Yuji
N1 - Funding Information:
This project was supported by the Modern Agricultural Technology System of Edible Fungi Industry in Fujian Province, China (Grant # K83139295), Natural Science Foundation of China (NSFC, Grant # 31401597), Fujian Agriculture and Forestry University Science and Technology Innovation Fund Project (Grant # KF2015050, CXZX2017409, CXZX2017410), Education and Scientific Research Projects of Young and Middle‐aged Teachers in Fujian Province (Grant # JT180115) and the Minjiang Scholar program 2018 supported by the College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, China.
Funding Information:
This project was supported by the Modern Agricultural Technology System of Edible Fungi Industry in Fujian Province, China (Grant # K83139295), Natural Science Foundation of China (NSFC, Grant # 31401597), Fujian Agriculture and Forestry University Science and Technology Innovation Fund Project (Grant # KF2015050, CXZX2017409, CXZX2017410), Education and Scientific Research Projects of Young and Middle-aged Teachers in Fujian Province (Grant # JT180115) and the Minjiang Scholar program 2018 supported by the College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, China.
Publisher Copyright:
© 2019 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Agaricus blazei Murill (ABM), a medicinal mushroom, has beneficial effects on various human metabolic diseases. The objective of this research was to evaluate the antioxidant and antidiabetic properties of ABM extracts (ethanol extract and ethyl acetate extract). The antioxidant activities of ABM ethanol extract (EE) and ethyl acetate extract (EA) were analyzed using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and hydroxyl radical scavenging assays and the reducing power using K3Fe(CN)6 in vitro. Moreover, the effects of EE and EA on α-glucosidase inhibitory activity and improving glucose uptake by HepG2 cells were investigated in vitro. The EA showed stronger antioxidant activity, as well as inhibition of α-glucosidase, compared to EE. The analysis of glucose uptake by HepG2 cells showed that EA had significant glucose-lowering activity and exhibited no difference compared to metformin. The results suggest that ABM extracts could improve the glucose uptake by HepG2 cells and thereby alleviate postprandial hyperglycemia. This investigation provides a strong rationale for further studies on the application of ABM to control type 2 diabetes.
AB - Agaricus blazei Murill (ABM), a medicinal mushroom, has beneficial effects on various human metabolic diseases. The objective of this research was to evaluate the antioxidant and antidiabetic properties of ABM extracts (ethanol extract and ethyl acetate extract). The antioxidant activities of ABM ethanol extract (EE) and ethyl acetate extract (EA) were analyzed using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and hydroxyl radical scavenging assays and the reducing power using K3Fe(CN)6 in vitro. Moreover, the effects of EE and EA on α-glucosidase inhibitory activity and improving glucose uptake by HepG2 cells were investigated in vitro. The EA showed stronger antioxidant activity, as well as inhibition of α-glucosidase, compared to EE. The analysis of glucose uptake by HepG2 cells showed that EA had significant glucose-lowering activity and exhibited no difference compared to metformin. The results suggest that ABM extracts could improve the glucose uptake by HepG2 cells and thereby alleviate postprandial hyperglycemia. This investigation provides a strong rationale for further studies on the application of ABM to control type 2 diabetes.
KW - Agaricus blazei Murill
KW - HepG2 cells
KW - antidiabetic activity
KW - antioxidant activity
KW - α-glucosidase
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U2 - 10.1002/fsn3.1310
DO - 10.1002/fsn3.1310
M3 - Article
AN - SCOPUS:85076092712
SN - 2048-7177
VL - 8
SP - 332
EP - 339
JO - Food Science and Nutrition
JF - Food Science and Nutrition
IS - 1
ER -