Assessment of antioxidant and antidiabetic properties of Agaricus blazei Murill extracts

Qi Wei, Yishu Zhan, Bingzhi Chen, Baogui Xie, Ting Fang, Sadhana Ravishankar, Yuji Jiang

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Agaricus blazei Murill (ABM), a medicinal mushroom, has beneficial effects on various human metabolic diseases. The objective of this research was to evaluate the antioxidant and antidiabetic properties of ABM extracts (ethanol extract and ethyl acetate extract). The antioxidant activities of ABM ethanol extract (EE) and ethyl acetate extract (EA) were analyzed using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and hydroxyl radical scavenging assays and the reducing power using K3Fe(CN)6 in vitro. Moreover, the effects of EE and EA on α-glucosidase inhibitory activity and improving glucose uptake by HepG2 cells were investigated in vitro. The EA showed stronger antioxidant activity, as well as inhibition of α-glucosidase, compared to EE. The analysis of glucose uptake by HepG2 cells showed that EA had significant glucose-lowering activity and exhibited no difference compared to metformin. The results suggest that ABM extracts could improve the glucose uptake by HepG2 cells and thereby alleviate postprandial hyperglycemia. This investigation provides a strong rationale for further studies on the application of ABM to control type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)332-339
Number of pages8
JournalFood Science and Nutrition
Issue number1
StatePublished - Jan 1 2020


  • Agaricus blazei Murill
  • HepG2 cells
  • antidiabetic activity
  • antioxidant activity
  • α-glucosidase

ASJC Scopus subject areas

  • Food Science


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