Assessment of a fluorescence-enhanced optical imaging system using the Hotelling observer

Amit K. Sahu, Amit Joshi, Matthew A. Kupinski, Eva M. Sevick-Muraca

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


This study represents a first attempt to assess the detection capability of a fluorescence-enhanced optical imaging system as quantified by the Hotelling observer. The imaging system is simulated by the diffusion approximation of the time-dependent radiative transfer equation, which describes near infra-red (NIR) light propagation through a breast phantom of clinically relevant volume. Random structures in the background are introduced using a lumpy-object model as a representation of anatomical structure as well as non-uniform distribution of disease markers. The systematic errors and noise associated with the actual experimental conditions are incorporated into the simulated boundary measurements to acquire imaging data sets. A large number of imaging data sets is considered in order to perform Hotelling observer studies. We find that the signal-to-noise ratio (SNR) of Hotelling observer (i) decreases as the strength of lumpy perturbations in the background increases, (ii) decreases as the target depth increases, and (iii) increases as excitation light leakage decreases, and reaches a maximum for filter optical density values of 5 or higher.

Original languageEnglish (US)
Pages (from-to)7642-7660
Number of pages19
JournalOptics Express
Issue number17
StatePublished - 2006

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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