@article{a9c1a4ac19b946a994521836a6541495,
title = "Assessing interactions between pnpla3 and dietary intake on liver steatosis in mexican-origin adults",
abstract = "Mexican-origin (MO) adults have among the highest rates of nonalcoholic fatty liver disease (NAFLD) placing them at increased risk of liver cancer. Evidence suggests that a single nucleotide polymorphism (SNP) in the PNPLA3 gene, rs738409, increases the risk and progression of NAFLD and may modify the relationship between certain dietary factors and liver steatosis. The purpose of this study was to identify whether interactions exist between specific dietary factors and rs738409 genotype status among MO adults in relation to levels of liver steatosis. We analyzed cross-sectional data from a sample of 288 MO adults. Participants completed at least two 24-h dietary recalls. Multiple linear regression was performed assuming an additive genetic model to test the main effects of several dietary variables on levels of hepatic steatosis, adjusting for covariates. To test for effect modification, the product of the genotype and the dietary variable was included as a covariate in the model. No significant association between dietary intake and level of hepatic steatosis was observed, nor any significant gene-diet interactions. Our findings suggest that dietary intake may have the same magnitude of protective or deleterious effect even among MO adults with high genetic risk for NAFLD and NAFLD progression.",
keywords = "Hispanic, Mexican-origin, NAFLD, Nonalcoholic fatty liver disease, Nutrigenetics, PNPLA3",
author = "Morrill, {Kristin E.} and Bland, {Victoria L.} and Klimentidis, {Yann C.} and Hingle, {Melanie D.} and Thomson, {Cynthia A.} and Garcia, {David O.}",
note = "Funding Information: This work was supported by the American Cancer Society (Institutional Cancer Research Grant number IRG-16-124-37), the National Institute on Minority Health and Health Disparities under award number K01MD014761 (Garcia), the National Cancer Institute T32 Cancer Prevention and Control Health Disparities Training Program award number 5T32CA078447-20 (Morrill), the University of Arizona Health Sciences, Center for Health Disparities Research Doctoral Dissertation Award, and the University of Arizona Core Facilities Pilot Program. The research utilized the University of Arizona Cancer Center Behavioral Measurement and Interventions Shared Resource (P30 CA023074). The authors acknowledge salary support by the University of Arizona Health Sciences Center for Border Health Disparities (CBORD) for K.E.M. We also would like to acknowledge our clinical partner, Arizona Liver Health, for providing space for our clinical study visits and for conducting all liver Fibroscans{\textregistered} as well as the University of Arizona Collaboratory for Metabolic Disease Prevention and Treatment for supporting the development of this manuscript. This analysis was conducted aspart of Morrill{\textquoteright}s PhD dissertation (found at http://repository.ari-zona.edu/ (accessed on 12 October 2020)). All copyrights to this work are held by Morrill. This manuscript has been reformatted and updated for publication in IJERPH. Funding Information: Funding: This work was supported by the American Cancer Society (Institutional Cancer Research Grant number IRG-16-124-37), the National Institute on Minority Health and Health Disparities under award number K01MD014761 (Garcia), the National Cancer Institute T32 Cancer Prevention and Control Health Disparities Training Program award number 5T32CA078447-20 (Morrill), the University of Arizona Health Sciences, Center for Health Disparities Research Doctoral Dissertation Award, and the University of Arizona Core Facilities Pilot Program. The research utilized the University of Arizona Cancer Center Behavioral Measurement and Interventions Shared Resource (P30 CA023074). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = jul,
day = "1",
doi = "10.3390/ijerph18137055",
language = "English (US)",
volume = "18",
journal = "International Journal of Environmental Research and Public Health",
issn = "1661-7827",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "13",
}