TY - JOUR
T1 - Aspochalasins I, J, and K
T2 - Three New Cytotoxic Cytochalasans of Aspergillus flavipes from the Rhizosphere of Ericameria laricifolia of the Sonoran Desert
AU - Zhou, Guang Xiong
AU - Wijeratne, E. M.Kithsiri
AU - Bigelow, Donna
AU - Pierson, Leland S.
AU - VanEtten, Hans D.
AU - Gunatilaka, A. A.Leslie
PY - 2004/3
Y1 - 2004/3
N2 - Bioassay-guided fractionation of a cytotoxic EtOAc extract of Aspergillus flavipes occurring in the rhizosphere of Ericameria laricifolia resulted in the isolation of three new cytochalasans, namely, aspochalasins I (1), J (2), and K (3), and four known cytochalasans, aspochalasins C (4), D (5), and E (6) and TMC-169 (7). The structures of compounds 1-3 were established on the basis of extensive 1D and 2D NMR spectroscopic analysis. All compounds exhibited weak to moderate cytotoxicity against NCI-H460, MCF-7, and SF-268 cancer cell lines, but none showed significant selectivity.
AB - Bioassay-guided fractionation of a cytotoxic EtOAc extract of Aspergillus flavipes occurring in the rhizosphere of Ericameria laricifolia resulted in the isolation of three new cytochalasans, namely, aspochalasins I (1), J (2), and K (3), and four known cytochalasans, aspochalasins C (4), D (5), and E (6) and TMC-169 (7). The structures of compounds 1-3 were established on the basis of extensive 1D and 2D NMR spectroscopic analysis. All compounds exhibited weak to moderate cytotoxicity against NCI-H460, MCF-7, and SF-268 cancer cell lines, but none showed significant selectivity.
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U2 - 10.1021/np030353m
DO - 10.1021/np030353m
M3 - Article
C2 - 15043404
AN - SCOPUS:1642547014
SN - 0163-3864
VL - 67
SP - 328
EP - 332
JO - Journal Of Natural Products
JF - Journal Of Natural Products
IS - 3
ER -