Ascorbic acid absorption in man - pharmacokinetic implications

Michael Mayersohn

doi:10.1016/0014-2999(72)90092-1

Ascorbic acid absorption in man - pharmacokinetic implications

Michael Mayersohn

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Several early literature reports have suggested the possible existence of a non-passive, saturable process for ascorbic acid absorption in man. The recent work of several investigators confirms the existence of such a mechanism. Based upon an analysis of the data provided by these investigators values of V_max and K_m have been calculated using the equations of saturable absorption kinetics. A method of oral dosing is suggested which should maximize the total amount of vitamin absorbed.

Original language	English (US)
Pages (from-to)	140-142
Number of pages	3
Journal	European Journal of Pharmacology
Volume	19
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(72)90092-1
State	Published - Jul 1972
Externally published	Yes

Keywords

Ascorbic acid absorption
Saturable absorption

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(72)90092-1

Cite this

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title = "Ascorbic acid absorption in man - pharmacokinetic implications",

abstract = "Several early literature reports have suggested the possible existence of a non-passive, saturable process for ascorbic acid absorption in man. The recent work of several investigators confirms the existence of such a mechanism. Based upon an analysis of the data provided by these investigators values of Vmax and Km have been calculated using the equations of saturable absorption kinetics. A method of oral dosing is suggested which should maximize the total amount of vitamin absorbed.",

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AB - Several early literature reports have suggested the possible existence of a non-passive, saturable process for ascorbic acid absorption in man. The recent work of several investigators confirms the existence of such a mechanism. Based upon an analysis of the data provided by these investigators values of Vmax and Km have been calculated using the equations of saturable absorption kinetics. A method of oral dosing is suggested which should maximize the total amount of vitamin absorbed.

KW - Ascorbic acid absorption

KW - Saturable absorption

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Ascorbic acid absorption in man - pharmacokinetic implications

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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