There have been few studies conducted to determine the efficiency of ascorbic acid absorption in humans. Differences in the extent of its absorption among individuals may contribute to the outcome of clinical trials. Ascorbic acid absorption in four subjects was investigated from several oral dosage forms containing 1 g of the vitamin (solution, tablet, chewable tablet, and timed‐release capsule). Approximately 85% of an intravenous dose was recovered in the urine as ascorbic acid and its major metabolites. In contrast, only ∼30% of the dose was recovered from the solution and tablet forms. A considerably smaller fraction of the dose (∼14%) was recovered from the timed‐release capsule. There was considerable intersubject variation in ascorbic acid absorption and there appeared to be good and poor absorbers of the vitamin. Consideration should be given to the influence of the extent of ascorbic acid absorption on the results of clinical trials.
- Absorption—ascorbic acid, comparison of several dosage forms, humans
- Ascorbic acid—comparison of absorption of several dosage forms, humans
- Vitamin C—comparison of absorption of several dosage forms, humans
ASJC Scopus subject areas
- Pharmaceutical Science