Artificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular Transport

Minkyu Kim; Wesley G. Chen; Jeon Woong Kang; Matthew J. Glassman; Katharina Ribbeck; Bradley D. Olsen

doi:10.1002/adma.201500752

Artificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular Transport

Minkyu Kim, Wesley G. Chen, Jeon Woong Kang, Matthew J. Glassman, Katharina Ribbeck, Bradley D. Olsen

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Nucleoporin-like polypeptide (NLP) hydrogels are developed by mimicking nucleoporins, proteins that form gel filters regulating transport into the nucleus. Using protein polymers of a minimal consensus repeat, the NLPs selectively enhance transport of cargo-carrier complexes similar to the natural nuclear pore system. The engineered protein gels additionally have tunable mechanical and transport properties and can be biosynthesized at high yield, making them promising materials for advanced separation technologies.

Original language	English (US)
Pages (from-to)	4207-4212
Number of pages	6
Journal	Advanced Materials
Volume	27
Issue number	28
DOIs	https://doi.org/10.1002/adma.201500752
State	Published - Jul 1 2015

Keywords

bioinspired materials
hydrogels
protein polymer design
selective permeability

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201500752

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title = "Artificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular Transport",

abstract = "Nucleoporin-like polypeptide (NLP) hydrogels are developed by mimicking nucleoporins, proteins that form gel filters regulating transport into the nucleus. Using protein polymers of a minimal consensus repeat, the NLPs selectively enhance transport of cargo-carrier complexes similar to the natural nuclear pore system. The engineered protein gels additionally have tunable mechanical and transport properties and can be biosynthesized at high yield, making them promising materials for advanced separation technologies.",

keywords = "bioinspired materials, hydrogels, protein polymer design, selective permeability",

author = "Minkyu Kim and Chen, {Wesley G.} and Kang, {Jeon Woong} and Glassman, {Matthew J.} and Katharina Ribbeck and Olsen, {Bradley D.}",

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AU - Kim, Minkyu

AU - Chen, Wesley G.

AU - Kang, Jeon Woong

AU - Glassman, Matthew J.

AU - Ribbeck, Katharina

AU - Olsen, Bradley D.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Nucleoporin-like polypeptide (NLP) hydrogels are developed by mimicking nucleoporins, proteins that form gel filters regulating transport into the nucleus. Using protein polymers of a minimal consensus repeat, the NLPs selectively enhance transport of cargo-carrier complexes similar to the natural nuclear pore system. The engineered protein gels additionally have tunable mechanical and transport properties and can be biosynthesized at high yield, making them promising materials for advanced separation technologies.

AB - Nucleoporin-like polypeptide (NLP) hydrogels are developed by mimicking nucleoporins, proteins that form gel filters regulating transport into the nucleus. Using protein polymers of a minimal consensus repeat, the NLPs selectively enhance transport of cargo-carrier complexes similar to the natural nuclear pore system. The engineered protein gels additionally have tunable mechanical and transport properties and can be biosynthesized at high yield, making them promising materials for advanced separation technologies.

KW - bioinspired materials

KW - hydrogels

KW - protein polymer design

KW - selective permeability

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Artificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular Transport

Abstract

Keywords

ASJC Scopus subject areas

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