TY - JOUR
T1 - Articulatory network reorganization in Parkinson's disease as assessed by multimodal MRI and acoustic measures
AU - Klobusiakova, Patricia
AU - Mekyska, Jiri
AU - Brabenec, Lubos
AU - Galaz, Zoltan
AU - Zvoncak, Vojtech
AU - Mucha, Jan
AU - Rapcsak, Steven Z.
AU - Rektorova, Irena
N1 - Funding Information:
This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 734718 (CoBeN), from a grant from the Czech Ministry of Health , NU20-04-00294 (Diagnostics of Lewy body diseases in prodromal stage based on multimodal data analysis), and from the European Regional Development Fund-Project ‘National infrastructure for biological and medical imaging’ (No CZ.02.1.01/0.0/0.0/16 013/0001775 ). We also acknowledge contribution of the core facility MAFIL of CEITEC supported by the MEYSCR ( LM2015062 Czech-BioImaging). For the research, the SIX Center infrastructure was used. Thanks to Anne Johnson for English language editing.
Publisher Copyright:
© 2021 The Authors
PY - 2021/3
Y1 - 2021/3
N2 - Introduction: Hypokinetic dysarthria (HD) is common in Parkinson's disease (PD). Our objective was to evaluate articulatory networks and their reorganization due to PD pathology in individuals without overt speech impairment using a multimodal MRI protocol and acoustic analysis of speech. Methods: A total of 34 PD patients with no subjective HD complaints and 25 age-matched healthy controls (HC) underwent speech task recordings, structural MRI, and reading task-induced and resting-state fMRI. Grey matter probability maps, task-induced activations, and resting-state functional connectivity within the regions engaged in speech production (ROIs) were assessed and compared between groups. Correlation with acoustic parameters was also performed. Results: PD patients as compared Tto HC displayed temporal decreases in speech loudness which were related to BOLD signal increases in the right-sided regions of the dorsal language pathway/articulatory network. Among those regions, activation of the right anterior cingulate was increased in PD as compared to HC. We also found bilateral posterior superior temporal gyrus (STG) GM loss in PD as compared to HC that was strongly associated with diadochokinetic (DDK) irregularity in the PD group. Task-induced activations of the left STG were increased in PD as compared to HC and were related to the DDK rate control. Conclusions: The results provide insight into the neural correlates of speech production control and distinct articulatory network reorganization in PD apparent already in patients without subjective speech impairment.
AB - Introduction: Hypokinetic dysarthria (HD) is common in Parkinson's disease (PD). Our objective was to evaluate articulatory networks and their reorganization due to PD pathology in individuals without overt speech impairment using a multimodal MRI protocol and acoustic analysis of speech. Methods: A total of 34 PD patients with no subjective HD complaints and 25 age-matched healthy controls (HC) underwent speech task recordings, structural MRI, and reading task-induced and resting-state fMRI. Grey matter probability maps, task-induced activations, and resting-state functional connectivity within the regions engaged in speech production (ROIs) were assessed and compared between groups. Correlation with acoustic parameters was also performed. Results: PD patients as compared Tto HC displayed temporal decreases in speech loudness which were related to BOLD signal increases in the right-sided regions of the dorsal language pathway/articulatory network. Among those regions, activation of the right anterior cingulate was increased in PD as compared to HC. We also found bilateral posterior superior temporal gyrus (STG) GM loss in PD as compared to HC that was strongly associated with diadochokinetic (DDK) irregularity in the PD group. Task-induced activations of the left STG were increased in PD as compared to HC and were related to the DDK rate control. Conclusions: The results provide insight into the neural correlates of speech production control and distinct articulatory network reorganization in PD apparent already in patients without subjective speech impairment.
KW - Acoustic analysis
KW - Hypokinetic dysarthria
KW - Parkinson's disease
KW - Resting-state functional connectivity
KW - Voxel-based morphometry
KW - fMRI
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U2 - 10.1016/j.parkreldis.2021.02.012
DO - 10.1016/j.parkreldis.2021.02.012
M3 - Article
C2 - 33609963
AN - SCOPUS:85101359663
SN - 1353-8020
VL - 84
SP - 122
EP - 128
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
ER -