Are placental Fas and Fas ligand gene polymorphisms associated with preeclampsia?

Satya S. Polavarapu, Lance A. Parton, Hima Maramreddy, Chaur Dong Hsu

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objective: Increased placental trophoblastic apoptosis has been reported in pregnancies complicated by preeclampsia. Fas-Fas ligand is one of the major signal transduction pathways of apoptosis. The objective of this study was to determine if placental Fas and Fas ligand gene polymorphisms differ between patients with and without preeclampsia. Study design: Forty-five singleton placentas were studied. Twenty-three placentas were from preeclamptic pregnancies and 22 were from normotensive controls. Genotyping was performed for Fas-1377, Fas-691, Fas-670, Fas ligand-844, Fas ligand-1174, Fas ligand-2777. Chi-square and Fisher's exact tests were used for statistical analysis. Results: There were no significant differences in maternal age, parity or race between the two groups. There were no significant differences in genotypes or allele frequencies for the Fas-1377, Fas-691, Fas-670, Fas ligand-844, Fas ligand-1174 and Fas ligand-2777. Conclusion: Immune intolerance of maternal and placental interaction plays an important role in the pathogenesis of preeclampsia. Our findings do not support the role of placental Fas and Fas ligand gene polymorphisms in the pathogenesis of preeclampsia.

Original languageEnglish (US)
Pages (from-to)34-38
Number of pages5
JournalPregnancy Hypertension
Volume3
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Keywords

  • Apoptosis
  • Fas-Fas ligand
  • Placental polymorphisms
  • Preeclampsia

ASJC Scopus subject areas

  • Internal Medicine
  • Obstetrics and Gynecology

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