Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic

Livia V. Patrono; Bram Vrancken; Matthias Budt; Ariane Düx; Sebastian Lequime; Sengül Boral; M. Thomas P. Gilbert; Jan F. Gogarten; Luisa Hoffmann; David Horst; Kevin Merkel; David Morens; Baptiste Prepoint; Jasmin Schlotterbeck; Verena J. Schuenemann; Marc A. Suchard; Jeffery K. Taubenberger; Luisa Tenkhoff; Christian Urban; Navena Widulin; Eduard Winter; Michael Worobey; Thomas Schnalke; Thorsten Wolff; Philippe Lemey; Sébastien Calvignac-Spencer

doi:10.1038/s41467-022-29614-9

Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic

Livia V. Patrono, Bram Vrancken, Matthias Budt, Ariane Düx, Sebastian Lequime, Sengül Boral, M. Thomas P. Gilbert, Jan F. Gogarten, Luisa Hoffmann, David Horst, Kevin Merkel, David Morens, Baptiste Prepoint, Jasmin Schlotterbeck, Verena J. Schuenemann, Marc A. Suchard, Jeffery K. Taubenberger, Luisa Tenkhoff, Christian Urban, Navena WidulinEduard Winter, Michael Worobey, Thomas Schnalke, Thorsten Wolff, Philippe Lemey, Sébastien Calvignac-Spencer

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32 Scopus citations

Abstract

The 1918 influenza pandemic was the deadliest respiratory pandemic of the 20th century and determined the genomic make-up of subsequent human influenza A viruses (IAV). Here, we analyze both the first 1918 IAV genomes from Europe and the first from samples prior to the autumn peak. 1918 IAV genomic diversity is consistent with a combination of local transmission and long-distance dispersal events. Comparison of genomes before and during the pandemic peak shows variation at two sites in the nucleoprotein gene associated with resistance to host antiviral response, pointing at a possible adaptation of 1918 IAV to humans. Finally, local molecular clock modeling suggests a pure pandemic descent of seasonal H1N1 IAV as an alternative to the hypothesis of origination through an intrasubtype reassortment.

Original language	English (US)
Article number	2314
Journal	Nature communications
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/s41467-022-29614-9
State	Published - Dec 2022
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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10.1038/s41467-022-29614-9

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Patrono, L. V., Vrancken, B., Budt, M., Düx, A., Lequime, S., Boral, S., Gilbert, M. T. P., Gogarten, J. F., Hoffmann, L., Horst, D., Merkel, K., Morens, D., Prepoint, B., Schlotterbeck, J., Schuenemann, V. J., Suchard, M. A., Taubenberger, J. K., Tenkhoff, L., Urban, C., ... Calvignac-Spencer, S. (2022). Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic. Nature communications, 13(1), Article 2314. https://doi.org/10.1038/s41467-022-29614-9

Patrono, LV, Vrancken, B, Budt, M, Düx, A, Lequime, S, Boral, S, Gilbert, MTP, Gogarten, JF, Hoffmann, L, Horst, D, Merkel, K, Morens, D, Prepoint, B, Schlotterbeck, J, Schuenemann, VJ, Suchard, MA, Taubenberger, JK, Tenkhoff, L, Urban, C, Widulin, N, Winter, E, Worobey, M, Schnalke, T, Wolff, T, Lemey, P & Calvignac-Spencer, S 2022, 'Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic', Nature communications, vol. 13, no. 1, 2314. https://doi.org/10.1038/s41467-022-29614-9

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abstract = "The 1918 influenza pandemic was the deadliest respiratory pandemic of the 20th century and determined the genomic make-up of subsequent human influenza A viruses (IAV). Here, we analyze both the first 1918 IAV genomes from Europe and the first from samples prior to the autumn peak. 1918 IAV genomic diversity is consistent with a combination of local transmission and long-distance dispersal events. Comparison of genomes before and during the pandemic peak shows variation at two sites in the nucleoprotein gene associated with resistance to host antiviral response, pointing at a possible adaptation of 1918 IAV to humans. Finally, local molecular clock modeling suggests a pure pandemic descent of seasonal H1N1 IAV as an alternative to the hypothesis of origination through an intrasubtype reassortment.",

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AU - Gilbert, M. Thomas P.

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AU - Merkel, Kevin

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AU - Schuenemann, Verena J.

AU - Suchard, Marc A.

AU - Taubenberger, Jeffery K.

AU - Tenkhoff, Luisa

AU - Urban, Christian

AU - Widulin, Navena

AU - Winter, Eduard

AU - Worobey, Michael

AU - Schnalke, Thomas

AU - Wolff, Thorsten

AU - Lemey, Philippe

AU - Calvignac-Spencer, Sébastien

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Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic

Abstract

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