@article{6a8ee80c76de4009ac8f7936b83714ce,
title = "Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites",
abstract = "Neuronal activity is an essential stimulus for induction of plasticity and normal development of the CNS. We have used differential cloning techniques to identify a novel immediate-early gene (IEG) cDNA that is rapidly induced in neurons by activity in models of adult and developmental plasticity. Both the mRNA and the encoded protein are enriched in neuronal dendrites. Analysis of the deduced amino acid sequence indicates a region of homology with α-spectrin, and the full-length protein, prepared by in vitro transcription/translation, coprecipitates with F-actin. Confocal microscopy of the native protein in hippocampal neurons demonstrates that the IEG-encoded protein is enriched in the subplasmalemmal cortex of the cell body and dendrites and thus colocalizes with the actin cytoskeletal matrix. Accordingly, we have termed the gene and encoded protein Arc (activity-regulated cytoskeleton-associated protein). Our observations suggest that Arc may play a role in activity-dependent plasticity of dendrites.",
author = "Lyford, {Gregory L.} and Kanato Yamagata and Kaufmann, {Walter E.} and Barnes, {Carol A.} and Sanders, {Laura K.} and Copeland, {Neal G.} and Gilbert, {Debra J.} and Jenkins, {Nancy A.} and Lanahan, {Anthony A.} and Worley, {Paul F.}",
note = "Funding Information: We thank M. Papapavlou and M. E. Barnsteadfor excellent technical assistance, Bruce Trapp for advice and support in the immunocytochemical analyses, Norman Barker for photographic assistance, and Ratan Bhat, Jennifer Fosnaugh, and Timothy Murphy for help in studies of Arc regulation. We also thank Daniel Nathans for help and support in the initial cloning of Arc. This work was supported by training grant MH18030 (G. L. L.), and grants EY09374 (P. F. W), AG09219 (C. A. B. and P. F. W.), H D01046 (W. E. K.), by grants from the Epilepsy Foundation of America (W. E. K.), the W. M. Keck Foundation (P. F. W.), the Krieger Mind/Brain Institute (P. F. W.), by a Merck clinician/scientist award (W. E. K.), and by the National Cancer Institute, Department of Health and Human Services, under contract NO1-CO-74101 with A. B. L.",
year = "1995",
month = feb,
doi = "10.1016/0896-6273(95)90299-6",
language = "English (US)",
volume = "14",
pages = "433--445",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "2",
}