Aptamers Targeting Hallmark Proteins of Neurodegeneration

Niloufar Mollasalehi, Liberty Francois-Moutal, David Porciani, Donald H. Burke, May Khanna

Research output: Contribution to journalReview articlepeer-review

Abstract

Neurodegeneration is a progressive deterioration of neural structures leading to cognitive or motor impairment of the affected patient. There is still no effective therapy for any of the most common neurodegenerative diseases (NDs) such as Alzheimer's or Parkinson's disease. Although NDs exhibit distinct clinical characteristics, many are characterized by the accumulation of misfolded proteins or peptide fragments in the brain and/or spinal cord. The presence of similar inclusion bodies in patients with diverse NDs provides a rationale for developing therapies directed at overlapping disease mechanisms. A novel targeting strategy involves the use of aptamers for therapeutic development. Aptamers are short nucleic acid ligands able to recognize molecular targets with high specificity and high affinity. Despite the fact that several academic groups have shown that aptamers have the potential to be used in therapeutic and diagnostic applications, their clinical translation is still limited. In this study, we describe aptamers that have been developed against proteins relevant to NDs, including prion protein and amyloid beta (Aβ), cell surface receptors and other cytoplasmic proteins. This review also describes advances in the application of these aptamers in imaging, protein detection, and protein quantification, and it provides insights about their accelerated clinical use for disease diagnosis and therapy.

Original languageEnglish (US)
Pages (from-to)235-250
Number of pages16
JournalNucleic Acid Therapeutics
Volume32
Issue number4
DOIs
StatePublished - Aug 1 2022
Externally publishedYes

Keywords

  • aptamers
  • neurodegenerative diseases
  • nucleic acid therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Drug Discovery

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