Approaches to meta analysis in genetic disorders

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Two examples of the use of meta-analysis have been described. In the first example of BRCA1, clinical and genotype data from families were combined in a single analysis. This provided a replication of the original study, delineated the clinical and ethnic characteristics of linked families and provided data on key recombinant individuals for gene localization. In the second example, results of analyses performed at the individual centres are being combined to test for linkage to chromosome 1 for hereditary prostate cancer. All centres are analysing their data in the same manner after completing a test file analysis, and the results will be combined instead of performing a combined analysis of raw data. Both approaches are useful and should be considered in studies of genetic disorders, especially in those of common disorders with a genetic component.

Original languageEnglish (US)
Pages (from-to)106-107
Number of pages2
JournalClinical and Experimental Allergy, Supplement
Issue number1
StatePublished - Apr 1998
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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