TY - JOUR
T1 - Applying the exposome concept to working life health
T2 - The EU EPHOR project
AU - Pronk, Anjoeka
AU - Loh, Miranda
AU - Kuijpers, Eelco
AU - Albin, Maria
AU - Selander, Jenny
AU - Godderis, Lode
AU - Ghosh, Manosij
AU - Vermeulen, Roel
AU - Peters, Susan
AU - Mehlum, Ingrid Sivesind
AU - Turner, Michelle C.
AU - Schlünssen, Vivi
AU - Goldberg, Marcel
AU - Kogevinas, Manolis
AU - Harding, Barbara N.
AU - Solovieva, Svetlana
AU - Garani-Papadatos, Tina
AU - Van Tongeren, Martie
AU - Stierum, Rob
N1 - Publisher Copyright:
© 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved.
PY - 2022/4/17
Y1 - 2022/4/17
N2 - Exposures at work have a major impact on noncommunicable diseases (NCDs). Current risk reduction policies and strategies are informed by existing scientific evidence, which is limited due to the challenges of studying the complex relationship between exposure at work and outside work and health. We define the working life exposome as all occupational and related nonoccupational exposures. The latter includes nonoccupational exposures that may be directly or indirectly influenced by or interact with the working life of the individual in their relation to health. The Exposome Project for Health and Occupational Research aims to advance knowledge on the complex working life exposures in relation to disease beyond the single high exposure-single health outcome paradigm, mapping and relating interrelated exposures to inherent biological pathways, key body functions, and health. This will be achieved by combining (1) large-scale harmonization and pooling of existing European cohorts systematically looking at multiple exposures and diseases, with (2) the collection of new high-resolution external and internal exposure data. Methods and tools to characterize the working life exposome will be developed and applied, including sensors, wearables, a harmonized job exposure matrix (EuroJEM), noninvasive biomonitoring, omics, data mining, and (bio)statistics. The toolbox of developed methods and knowledge will be made available to policy makers, occupational health practitioners, and scientists. Advanced knowledge on working life exposures in relation to NCDs will serve as a basis for evidence-based and cost-effective preventive policies and actions. The toolbox will also enable future scientists to further expand the working life exposome knowledge base.
AB - Exposures at work have a major impact on noncommunicable diseases (NCDs). Current risk reduction policies and strategies are informed by existing scientific evidence, which is limited due to the challenges of studying the complex relationship between exposure at work and outside work and health. We define the working life exposome as all occupational and related nonoccupational exposures. The latter includes nonoccupational exposures that may be directly or indirectly influenced by or interact with the working life of the individual in their relation to health. The Exposome Project for Health and Occupational Research aims to advance knowledge on the complex working life exposures in relation to disease beyond the single high exposure-single health outcome paradigm, mapping and relating interrelated exposures to inherent biological pathways, key body functions, and health. This will be achieved by combining (1) large-scale harmonization and pooling of existing European cohorts systematically looking at multiple exposures and diseases, with (2) the collection of new high-resolution external and internal exposure data. Methods and tools to characterize the working life exposome will be developed and applied, including sensors, wearables, a harmonized job exposure matrix (EuroJEM), noninvasive biomonitoring, omics, data mining, and (bio)statistics. The toolbox of developed methods and knowledge will be made available to policy makers, occupational health practitioners, and scientists. Advanced knowledge on working life exposures in relation to NCDs will serve as a basis for evidence-based and cost-effective preventive policies and actions. The toolbox will also enable future scientists to further expand the working life exposome knowledge base.
KW - Exposome
KW - Noncommunicable disease
KW - Occupational
KW - Working life
UR - http://www.scopus.com/inward/record.url?scp=85125133708&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85125133708&partnerID=8YFLogxK
U2 - 10.1097/EE9.0000000000000185
DO - 10.1097/EE9.0000000000000185
M3 - Article
AN - SCOPUS:85125133708
SN - 2474-7882
VL - 6
SP - E185
JO - Environmental Epidemiology
JF - Environmental Epidemiology
IS - 2
ER -