Application of hitherto unexplored macrocyclization strategies in the epothilone series: novel epothilone analogs by total synthesis

Jon T. Njardarson; Kaustav Biswas; Samuel J. Danishefsky

doi:10.1039/b209941a

Application of hitherto unexplored macrocyclization strategies in the epothilone series: novel epothilone analogs by total synthesis

Jon T. Njardarson
, Kaustav Biswas
, Samuel J. Danishefsky

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

A total synthesis of Epothilone 490 and a synthesis of 11-hydroxy dEpoB utilizing a vinyl-boronate cross-metathesis followed by a Suzuki macrocyclization. A mild route to reach aldehydes from terminal olefins, anticipating Nozaki–Kishi macrocyclization is described.

Original language	English (US)
Pages (from-to)	2759-2761
Number of pages	3
Journal	Chemical Communications
Volume	2
Issue number	23
DOIs	https://doi.org/10.1039/b209941a
State	Published - 2002
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/b209941a

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title = "Application of hitherto unexplored macrocyclization strategies in the epothilone series: novel epothilone analogs by total synthesis",

abstract = "A total synthesis of Epothilone 490 and a synthesis of 11-hydroxy dEpoB utilizing a vinyl-boronate cross-metathesis followed by a Suzuki macrocyclization. A mild route to reach aldehydes from terminal olefins, anticipating Nozaki–Kishi macrocyclization is described.",

author = "Njardarson, \{Jon T.\} and Kaustav Biswas and Danishefsky, \{Samuel J.\}",

year = "2002",

doi = "10.1039/b209941a",

language = "English (US)",

volume = "2",

pages = "2759--2761",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

number = "23",

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T1 - Application of hitherto unexplored macrocyclization strategies in the epothilone series

T2 - novel epothilone analogs by total synthesis

AU - Njardarson, Jon T.

AU - Biswas, Kaustav

AU - Danishefsky, Samuel J.

PY - 2002

Y1 - 2002

N2 - A total synthesis of Epothilone 490 and a synthesis of 11-hydroxy dEpoB utilizing a vinyl-boronate cross-metathesis followed by a Suzuki macrocyclization. A mild route to reach aldehydes from terminal olefins, anticipating Nozaki–Kishi macrocyclization is described.

AB - A total synthesis of Epothilone 490 and a synthesis of 11-hydroxy dEpoB utilizing a vinyl-boronate cross-metathesis followed by a Suzuki macrocyclization. A mild route to reach aldehydes from terminal olefins, anticipating Nozaki–Kishi macrocyclization is described.

UR - https://www.scopus.com/pages/publications/0036436316

UR - https://www.scopus.com/pages/publications/0036436316#tab=citedBy

U2 - 10.1039/b209941a

DO - 10.1039/b209941a

M3 - Article

C2 - 12478733

AN - SCOPUS:0036436316

SN - 1359-7345

VL - 2

SP - 2759

EP - 2761

JO - Chemical Communications

JF - Chemical Communications

IS - 23

ER -

Application of hitherto unexplored macrocyclization strategies in the epothilone series: novel epothilone analogs by total synthesis

Abstract

ASJC Scopus subject areas

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