ApoE4 confers better spatial memory than apoE3 in young adult hAPP-Yac/apoE-TR mice

Pierre Henri Moreau; Jean Bastien Bott; Celina Zerbinatti; John Joseph Renger; Christian Kelche; Jean Christophe Cassel; Chantal Mathis

doi:10.1016/j.bbr.2012.12.043

ApoE4 confers better spatial memory than apoE3 in young adult hAPP-Yac/apoE-TR mice

Pierre Henri Moreau
, Jean Bastien Bott
, Celina Zerbinatti
, John Joseph Renger
, Christian Kelche
, Jean Christophe Cassel
, Chantal Mathis

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The APOE-e{open}4 allele is associated with increased cognitive decline during normal aging and Alzheimer's disease. However, several studies intriguingly found a beneficial effect on cognition in young adult human APOE-e{open}4 carriers. Here, we show that 3-month old bigenic hAPP-Yac/apoE4-TR mice outperformed their hAPP-Yac/apoE3-TR counterparts on learning and memory performances in the highly hippocampus-dependent, hidden-platform version of the Morris water maze task. The two mouse lines did not differ in a non-spatial visible-platform version of the task. This hAPP-Yac/apoE-TR model may thus provide a useful tool to study the mechanisms involved in the antagonistic pleiotropic effects of APOE-e{open}4 on cognitive functions.

Original language	English (US)
Pages (from-to)	1-5
Number of pages	5
Journal	Behavioural Brain Research
Volume	243
Issue number	1
DOIs	https://doi.org/10.1016/j.bbr.2012.12.043
State	Published - Apr 5 2013
Externally published	Yes

Keywords

Antagonist pleiotropic effect
Apolipoprotein E
Cognition

ASJC Scopus subject areas

Behavioral Neuroscience

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10.1016/j.bbr.2012.12.043

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title = "ApoE4 confers better spatial memory than apoE3 in young adult hAPP-Yac/apoE-TR mice",

abstract = "The APOE-e\{open\}4 allele is associated with increased cognitive decline during normal aging and Alzheimer's disease. However, several studies intriguingly found a beneficial effect on cognition in young adult human APOE-e\{open\}4 carriers. Here, we show that 3-month old bigenic hAPP-Yac/apoE4-TR mice outperformed their hAPP-Yac/apoE3-TR counterparts on learning and memory performances in the highly hippocampus-dependent, hidden-platform version of the Morris water maze task. The two mouse lines did not differ in a non-spatial visible-platform version of the task. This hAPP-Yac/apoE-TR model may thus provide a useful tool to study the mechanisms involved in the antagonistic pleiotropic effects of APOE-e\{open\}4 on cognitive functions.",

keywords = "Antagonist pleiotropic effect, Apolipoprotein E, Cognition",

author = "Moreau, \{Pierre Henri\} and Bott, \{Jean Bastien\} and Celina Zerbinatti and Renger, \{John Joseph\} and Christian Kelche and Cassel, \{Jean Christophe\} and Chantal Mathis",

note = "Funding Information: We thank Jean-Cosme Dodart for his help in initiating the present work and Elise Vogel for technical assistance. This work was supported by a grant from Alsace Alzheimer Haut-Rhin ( 68 ), graduate fellowships from the R{\'e}gion Alsace (PHM) and the Minist{\`e}re de l{\textquoteright}Enseignement Sup{\'e}rieur et de la Recherche (JBB) , and by the Universit{\'e} de Strasbourg and the Centre National de la Recherche Scientifique . ",

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doi = "10.1016/j.bbr.2012.12.043",

language = "English (US)",

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T1 - ApoE4 confers better spatial memory than apoE3 in young adult hAPP-Yac/apoE-TR mice

AU - Moreau, Pierre Henri

AU - Bott, Jean Bastien

AU - Zerbinatti, Celina

AU - Renger, John Joseph

AU - Kelche, Christian

AU - Cassel, Jean Christophe

AU - Mathis, Chantal

N1 - Funding Information: We thank Jean-Cosme Dodart for his help in initiating the present work and Elise Vogel for technical assistance. This work was supported by a grant from Alsace Alzheimer Haut-Rhin ( 68 ), graduate fellowships from the Région Alsace (PHM) and the Ministère de l’Enseignement Supérieur et de la Recherche (JBB) , and by the Université de Strasbourg and the Centre National de la Recherche Scientifique .

PY - 2013/4/5

Y1 - 2013/4/5

N2 - The APOE-e{open}4 allele is associated with increased cognitive decline during normal aging and Alzheimer's disease. However, several studies intriguingly found a beneficial effect on cognition in young adult human APOE-e{open}4 carriers. Here, we show that 3-month old bigenic hAPP-Yac/apoE4-TR mice outperformed their hAPP-Yac/apoE3-TR counterparts on learning and memory performances in the highly hippocampus-dependent, hidden-platform version of the Morris water maze task. The two mouse lines did not differ in a non-spatial visible-platform version of the task. This hAPP-Yac/apoE-TR model may thus provide a useful tool to study the mechanisms involved in the antagonistic pleiotropic effects of APOE-e{open}4 on cognitive functions.

AB - The APOE-e{open}4 allele is associated with increased cognitive decline during normal aging and Alzheimer's disease. However, several studies intriguingly found a beneficial effect on cognition in young adult human APOE-e{open}4 carriers. Here, we show that 3-month old bigenic hAPP-Yac/apoE4-TR mice outperformed their hAPP-Yac/apoE3-TR counterparts on learning and memory performances in the highly hippocampus-dependent, hidden-platform version of the Morris water maze task. The two mouse lines did not differ in a non-spatial visible-platform version of the task. This hAPP-Yac/apoE-TR model may thus provide a useful tool to study the mechanisms involved in the antagonistic pleiotropic effects of APOE-e{open}4 on cognitive functions.

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KW - Cognition

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ApoE4 confers better spatial memory than apoE3 in young adult hAPP-Yac/apoE-TR mice

Abstract

Keywords

ASJC Scopus subject areas

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