ApoE4 confers better spatial memory than apoE3 in young adult hAPP-Yac/apoE-TR mice

Pierre Henri Moreau, Jean Bastien Bott, Celina Zerbinatti, John Joseph Renger, Christian Kelche, Jean Christophe Cassel, Chantal Mathis

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The APOE-e{open}4 allele is associated with increased cognitive decline during normal aging and Alzheimer's disease. However, several studies intriguingly found a beneficial effect on cognition in young adult human APOE-e{open}4 carriers. Here, we show that 3-month old bigenic hAPP-Yac/apoE4-TR mice outperformed their hAPP-Yac/apoE3-TR counterparts on learning and memory performances in the highly hippocampus-dependent, hidden-platform version of the Morris water maze task. The two mouse lines did not differ in a non-spatial visible-platform version of the task. This hAPP-Yac/apoE-TR model may thus provide a useful tool to study the mechanisms involved in the antagonistic pleiotropic effects of APOE-e{open}4 on cognitive functions.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalBehavioural Brain Research
Issue number1
StatePublished - Apr 5 2013
Externally publishedYes


  • Antagonist pleiotropic effect
  • Apolipoprotein E
  • Cognition

ASJC Scopus subject areas

  • Behavioral Neuroscience


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