@inproceedings{e829bc7a75aa4ae5a36ec6c282b9db07,
title = "Aperture Size Selection for Improved Brain Tumor Detection and Quantification in Multi-Pinhole 123I-CLINDE SPECT Imaging",
abstract = "A next-generation multi-pinhole system dedicated to brain SPECT imaging is being constructed by our research team, which we call AdaptiSPECT-C. The system prototype used herein consists of 25 square detector modules and a total of 100 apertures grouped by 4 per module. The system is specifically designed for multi-purpose brain imaging and capable of adapting in real-time each aperture size and whether it is open or shuttered closed. The use of such system would provide optimum high-performance patient-personalized imaging for a wide range of brain imaging tasks. In this work we investigated the effect of pinhole diameter variation on spherical tumor quantification for the promising brain tumor imaging agent 123I-CLINDE. To assess the quality of the images reconstructed for the different aperture sizes, we used a customized multiple-sphere tumor phantom derived from the XCAT software with a tumor size of 1 cm in diameter. Our results suggest through quantification and visual inspection that an aperture diameter in the range of 2 to 5 mm in diameter for the adaptive AdaptiSPECT-C system is likely the most suited for high performance brain tumor 123I-CLINDE imaging. In addition, our study concludes that a 4 mm pinhole diameter given its excellent spatial-resolution-to-sensitivity trade-off is promising for scout acquisition in localizing target tumor regions within the brain. We have initiated a task-based performance on the tumor detection and localization accuracy for a range of simulated tumor sizes using the channelized non-pre-whitening (CNPW) matched-filter scanning-observer.",
keywords = "GATE Monte-Carlo simulation, Glioma, I-CLINDE SPECT imaging, Next-generation clinical system, Pinhole diameter selection, Quantification",
author = "Benjamin Auer and Kalluri, {Kesava S.} and Abayazeed, {Aly H.} and {de Beenhouwer}, Jan and Navid Zeraatkar and Clifford Lindsay and Momsen, {Neil C.} and Richards, {R. Garrett} and Micaehla May and Kupinski, {Matthew A.} and Kuo, {Phillip H.} and Furenlid, {Lars R.} and King, {Michael A.}",
note = "Publisher Copyright: {\textcopyright} 2020 IEEE; 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2020 ; Conference date: 31-10-2020 Through 07-11-2020",
year = "2020",
doi = "10.1109/NSS/MIC42677.2020.9508019",
language = "English (US)",
series = "2020 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2020",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
booktitle = "2020 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2020",
}