Antiplatelet effects of oral diltiazem, propranolol, and their combination.

ME Ring, JJ Corrigan, PE Fenster

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


1. The antiplatelet effects of a single oral dose of the calcium entry blocker diltiazem (60 mg), the beta‐adrenoceptor blocker propranolol (40 mg), and their combination were studied in five healthy subjects. 2. Platelet aggregation and ATP release induced by adrenaline and ADP and ADP induced platelet thromboxane A2 generation were significantly inhibited (P less than 0.05) by either diltiazem or propranolol, although propranolol tended to have greater inhibitory effects on platelet function than diltiazem that did not reach statistical significance. 3. Combination therapy resulted in additive antiplatelet effects that were significantly (P less than 0.05) greater than either drug alone. 4. These data indicate that combined administration of a calcium entry blocker and a beta‐adrenoceptor blocker results in additive inhibitory effects on platelet function. These effects may mediate part of the therapeutic efficacy of combination therapy in patients with coronary artery disease. 1987 The British Pharmacological Society

Original languageEnglish (US)
Pages (from-to)615-620
Number of pages6
JournalBritish Journal of Clinical Pharmacology
Issue number5
StatePublished - Nov 1987

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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