Antioxidant properties of nitric oxide in cellular physiological and pathophysiological mechanisms. The implications of biological balance between •NO and oxidative stress

Lisa A. Ridnour; Douglas D. Thomas; Daniele Mancardi; Sonia Donzelli; Nazerrano Paolocci; Pasquale Pagliaro; Katrina M. Miranda; Murali Krishna; John Fukuto; Matthew B. Grisham; James B. Mitchell; Michael G. Espey; David A. Wink

doi:10.2174/1568014043355311

Antioxidant properties of nitric oxide in cellular physiological and pathophysiological mechanisms. The implications of biological balance between ^•NO and oxidative stress

Lisa A. Ridnour, Douglas D. Thomas, Daniele Mancardi, Sonia Donzelli, Nazerrano Paolocci, Pasquale Pagliaro, Katrina M. Miranda, Murali Krishna, John Fukuto, Matthew B. Grisham, James B. Mitchell, Michael G. Espey, David A. Wink

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

The function of nitric oxide (^•NO) in pathophysiology remains confounding as both protective and cytotoxic effects of ^•NO have been demonstrated in many disease processes. Nitric oxide chemistry culminating in the generation of oxidative as well as nitrosative intermediates have generally been proposed as mediators of pathophysiology and have overshadowed the antioxidant capabilities of ^•NO. However, the counteracting role of ^•NO in providing a balance under conditions of oxidative and nitrosative stress has been underappreciated. The purpose of this review is the discussion of the role of ^•NO as an antioxidant and interceptor of more potent reactive intermediates in normal physiology and disease.

Original language	English (US)
Pages (from-to)	181-188
Number of pages	8
Journal	Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents
Volume	3
Issue number	3
DOIs	https://doi.org/10.2174/1568014043355311
State	Published - Sep 2004

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Pharmacology

Access to Document

10.2174/1568014043355311

Cite this

Ridnour, L. A., Thomas, D. D., Mancardi, D., Donzelli, S., Paolocci, N., Pagliaro, P., Miranda, K. M., Krishna, M., Fukuto, J., Grisham, M. B., Mitchell, J. B., Espey, M. G., & Wink, D. A. (2004). Antioxidant properties of nitric oxide in cellular physiological and pathophysiological mechanisms. The implications of biological balance between ^•NO and oxidative stress. Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents, 3(3), 181-188. https://doi.org/10.2174/1568014043355311

Antioxidant properties of nitric oxide in cellular physiological and pathophysiological mechanisms. The implications of biological balance between ^•NO and oxidative stress. / Ridnour, Lisa A.; Thomas, Douglas D.; Mancardi, Daniele et al.
In: Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents, Vol. 3, No. 3, 09.2004, p. 181-188.

Research output: Contribution to journal › Review article › peer-review

Ridnour, LA, Thomas, DD, Mancardi, D, Donzelli, S, Paolocci, N, Pagliaro, P, Miranda, KM, Krishna, M, Fukuto, J, Grisham, MB, Mitchell, JB, Espey, MG & Wink, DA 2004, 'Antioxidant properties of nitric oxide in cellular physiological and pathophysiological mechanisms. The implications of biological balance between ^•NO and oxidative stress', Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents, vol. 3, no. 3, pp. 181-188. https://doi.org/10.2174/1568014043355311

Ridnour LA, Thomas DD, Mancardi D, Donzelli S, Paolocci N, Pagliaro P et al. Antioxidant properties of nitric oxide in cellular physiological and pathophysiological mechanisms. The implications of biological balance between ^•NO and oxidative stress. Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents. 2004 Sep;3(3):181-188. doi: 10.2174/1568014043355311

@article{a85de55045374cfe810381302a0918cf,

title = "Antioxidant properties of nitric oxide in cellular physiological and pathophysiological mechanisms. The implications of biological balance between •NO and oxidative stress",

abstract = "The function of nitric oxide (•NO) in pathophysiology remains confounding as both protective and cytotoxic effects of •NO have been demonstrated in many disease processes. Nitric oxide chemistry culminating in the generation of oxidative as well as nitrosative intermediates have generally been proposed as mediators of pathophysiology and have overshadowed the antioxidant capabilities of •NO. However, the counteracting role of •NO in providing a balance under conditions of oxidative and nitrosative stress has been underappreciated. The purpose of this review is the discussion of the role of •NO as an antioxidant and interceptor of more potent reactive intermediates in normal physiology and disease.",

author = "Ridnour, {Lisa A.} and Thomas, {Douglas D.} and Daniele Mancardi and Sonia Donzelli and Nazerrano Paolocci and Pasquale Pagliaro and Miranda, {Katrina M.} and Murali Krishna and John Fukuto and Grisham, {Matthew B.} and Mitchell, {James B.} and Espey, {Michael G.} and Wink, {David A.}",

year = "2004",

month = sep,

doi = "10.2174/1568014043355311",

language = "English (US)",

volume = "3",

pages = "181--188",

journal = "Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents",

issn = "1568-0142",

publisher = "Bentham Science Publishers",

number = "3",

}

TY - JOUR

T1 - Antioxidant properties of nitric oxide in cellular physiological and pathophysiological mechanisms. The implications of biological balance between •NO and oxidative stress

AU - Ridnour, Lisa A.

AU - Thomas, Douglas D.

AU - Mancardi, Daniele

AU - Donzelli, Sonia

AU - Paolocci, Nazerrano

AU - Pagliaro, Pasquale

AU - Miranda, Katrina M.

AU - Krishna, Murali

AU - Fukuto, John

AU - Grisham, Matthew B.

AU - Mitchell, James B.

AU - Espey, Michael G.

AU - Wink, David A.

PY - 2004/9

Y1 - 2004/9

N2 - The function of nitric oxide (•NO) in pathophysiology remains confounding as both protective and cytotoxic effects of •NO have been demonstrated in many disease processes. Nitric oxide chemistry culminating in the generation of oxidative as well as nitrosative intermediates have generally been proposed as mediators of pathophysiology and have overshadowed the antioxidant capabilities of •NO. However, the counteracting role of •NO in providing a balance under conditions of oxidative and nitrosative stress has been underappreciated. The purpose of this review is the discussion of the role of •NO as an antioxidant and interceptor of more potent reactive intermediates in normal physiology and disease.

AB - The function of nitric oxide (•NO) in pathophysiology remains confounding as both protective and cytotoxic effects of •NO have been demonstrated in many disease processes. Nitric oxide chemistry culminating in the generation of oxidative as well as nitrosative intermediates have generally been proposed as mediators of pathophysiology and have overshadowed the antioxidant capabilities of •NO. However, the counteracting role of •NO in providing a balance under conditions of oxidative and nitrosative stress has been underappreciated. The purpose of this review is the discussion of the role of •NO as an antioxidant and interceptor of more potent reactive intermediates in normal physiology and disease.

UR - http://www.scopus.com/inward/record.url?scp=4344622304&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4344622304&partnerID=8YFLogxK

U2 - 10.2174/1568014043355311

DO - 10.2174/1568014043355311

M3 - Review article

AN - SCOPUS:4344622304

SN - 1568-0142

VL - 3

SP - 181

EP - 188

JO - Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents

JF - Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents

IS - 3

ER -

Antioxidant properties of nitric oxide in cellular physiological and pathophysiological mechanisms. The implications of biological balance between ^•NO and oxidative stress

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this