Antioxidant activity of disoscorea and dehydroepiandrosterone (DHEA) in older humans

Mohsen Araghiniknam; Sangbun Chung; Tresa Nelson-White; Cleamond Eskelson; Ronald R. Watson

doi:10.1016/0024-3205(96)00396-7

Antioxidant activity of disoscorea and dehydroepiandrosterone (DHEA) in older humans

Mohsen Araghiniknam, Sangbun Chung, Tresa Nelson-White, Cleamond Eskelson, Ronald R. Watson

Health Promotion Sciences

Research output: Contribution to journal › Article › peer-review

125 Scopus citations

Abstract

Dioscorea is a yam steroid extract used in commercial steroid synthesis and consumed by people. DHEA is a steroid which declines with age, but without known activity. This study was designed to determine whether dioscorea supplementation could increase serum dehydroepiandrosterone sulfate (DHEAS) in humans and modulate lipid levels in older people. The subjects were selected volunteers aged 65-82 years. The serum DHEAS level, lipid peroxidation and lipid profile were assessed. Three weeks of dioscorea supplementation had no affect on serum DHEAS level. However DHEA intake of 85 mg/day increased serum DHEA levels 100.3%. DHEA and dioscorea significantly reduced serum lipid peroxidation, lowered serum triglycerides, phospholipid and increased HDL levels. Both DHEA and the steroid yam extract, dioscorea, have significant activities as antioxidant to modify serum lipid levels.

Original language	English (US)
Pages (from-to)	PL147-PL157
Journal	Life Sciences
Volume	59
Issue number	11
DOIs	https://doi.org/10.1016/0024-3205(96)00396-7
State	Published - Aug 9 1996

Keywords

DHEA
Dehydroepiandrosterone
Dioscorea
Lipids
Oxidative damage
Yam

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(96)00396-7

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title = "Antioxidant activity of disoscorea and dehydroepiandrosterone (DHEA) in older humans",

abstract = "Dioscorea is a yam steroid extract used in commercial steroid synthesis and consumed by people. DHEA is a steroid which declines with age, but without known activity. This study was designed to determine whether dioscorea supplementation could increase serum dehydroepiandrosterone sulfate (DHEAS) in humans and modulate lipid levels in older people. The subjects were selected volunteers aged 65-82 years. The serum DHEAS level, lipid peroxidation and lipid profile were assessed. Three weeks of dioscorea supplementation had no affect on serum DHEAS level. However DHEA intake of 85 mg/day increased serum DHEA levels 100.3%. DHEA and dioscorea significantly reduced serum lipid peroxidation, lowered serum triglycerides, phospholipid and increased HDL levels. Both DHEA and the steroid yam extract, dioscorea, have significant activities as antioxidant to modify serum lipid levels.",

keywords = "DHEA, Dehydroepiandrosterone, Dioscorea, Lipids, Oxidative damage, Yam",

author = "Mohsen Araghiniknam and Sangbun Chung and Tresa Nelson-White and Cleamond Eskelson and Watson, {Ronald R.}",

note = "Funding Information: This study was supported by a grant from Wallace Genetics Foundation, Inc. We appreciate advise of Sam Queen. We sincerely thank Dr. M. L. Fernandez from the Department of Nutrition, Dr. G.H. Atkinson, and Dr C. Brown at Department of Biochemistry for kind advise and using their facilities.",

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AU - Nelson-White, Tresa

AU - Eskelson, Cleamond

AU - Watson, Ronald R.

N1 - Funding Information: This study was supported by a grant from Wallace Genetics Foundation, Inc. We appreciate advise of Sam Queen. We sincerely thank Dr. M. L. Fernandez from the Department of Nutrition, Dr. G.H. Atkinson, and Dr C. Brown at Department of Biochemistry for kind advise and using their facilities.

PY - 1996/8/9

Y1 - 1996/8/9

N2 - Dioscorea is a yam steroid extract used in commercial steroid synthesis and consumed by people. DHEA is a steroid which declines with age, but without known activity. This study was designed to determine whether dioscorea supplementation could increase serum dehydroepiandrosterone sulfate (DHEAS) in humans and modulate lipid levels in older people. The subjects were selected volunteers aged 65-82 years. The serum DHEAS level, lipid peroxidation and lipid profile were assessed. Three weeks of dioscorea supplementation had no affect on serum DHEAS level. However DHEA intake of 85 mg/day increased serum DHEA levels 100.3%. DHEA and dioscorea significantly reduced serum lipid peroxidation, lowered serum triglycerides, phospholipid and increased HDL levels. Both DHEA and the steroid yam extract, dioscorea, have significant activities as antioxidant to modify serum lipid levels.

AB - Dioscorea is a yam steroid extract used in commercial steroid synthesis and consumed by people. DHEA is a steroid which declines with age, but without known activity. This study was designed to determine whether dioscorea supplementation could increase serum dehydroepiandrosterone sulfate (DHEAS) in humans and modulate lipid levels in older people. The subjects were selected volunteers aged 65-82 years. The serum DHEAS level, lipid peroxidation and lipid profile were assessed. Three weeks of dioscorea supplementation had no affect on serum DHEAS level. However DHEA intake of 85 mg/day increased serum DHEA levels 100.3%. DHEA and dioscorea significantly reduced serum lipid peroxidation, lowered serum triglycerides, phospholipid and increased HDL levels. Both DHEA and the steroid yam extract, dioscorea, have significant activities as antioxidant to modify serum lipid levels.

KW - DHEA

KW - Dehydroepiandrosterone

KW - Dioscorea

KW - Lipids

KW - Oxidative damage

KW - Yam

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Antioxidant activity of disoscorea and dehydroepiandrosterone (DHEA) in older humans

Abstract

Keywords

ASJC Scopus subject areas

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