Antimicrobial and cytotoxic effects of Mexican medicinal plants

Maria Del Rosario Jacobo-Salcedo; Angel Josabad Alonso-Castro; Luis A. Salazar-Olivo; Candy Carranza-Alvarez; Luis Ańgel Gonzaĺez-Espińdola; Fabiola Domińguez; Sandra Patricia Maciel-Torres; Concepcioń Garciá-Lujan; Marisela Del Rocio Gonzaĺez-Martińez; Maricela Goḿez-Sańchez; Eduardo Estrada-Castilloń; Rocio Zapata-Bustos; Pedro Medellin-Milań; Alejandro Garciá-Carrancá

doi:10.1177/1934578x1100601234

Antimicrobial and cytotoxic effects of Mexican medicinal plants

Maria Del Rosario Jacobo-Salcedo, Angel Josabad Alonso-Castro, Luis A. Salazar-Olivo, Candy Carranza-Alvarez, Luis Ańgel Gonzaĺez-Espińdola, Fabiola Domińguez, Sandra Patricia Maciel-Torres, Concepcioń Garciá-Lujan, Marisela Del Rocio Gonzaĺez-Martińez, Maricela Goḿez-Sańchez, Eduardo Estrada-Castilloń, Rocio Zapata-Bustos, Pedro Medellin-Milań, Alejandro Garciá-Carrancá

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The antimicrobial effects of the Mexican medicinal plants Guazuma ulmifolia, Justicia spicigera, Opuntia joconostle, O. leucotricha, Parkinsonia aculeata, Phoradendron longifolium, P. serotinum, Psittacanthus calyculatus, Tecoma stans and Teucrium cubense were tested against several human multi-drug resistant pathogens, including three Gram (+) and five Gram (-) bacterial species and three fungal species using the disk-diffusion assay. The cytotoxicity of plant extracts on human cancer cell lines and human normal non-cancerous cells was also evaluated using the MTT assay. Phoradendron longifolium, Teucrium cubense, Opuntia joconostle, Tecoma stans and Guazuma ulmifolia showed potent antimicrobial effects against at least one multidrug-resistant microorganism (inhibition zone > 15 mm). Only Justicia spicigera and Phoradendron serotinum extracts exerted active cytotoxic effects on human breast cancer cells (IC₅₀≤30 μg/mL). The results showed that Guazuma ulmifolia produced potent antimicrobial effects against Candida albicans and Acinetobacter lwoffii, whereas Justicia spicigera and Phoradendron serotinum exerted the highest toxic effects on MCF-7 and HeLa, respectively, which are human cancer cell lines. These three plant species may be important sources of antimicrobial and cytotoxic agents.

Original language	English (US)
Pages (from-to)	1925-1928
Number of pages	4
Journal	Natural Product Communications
Volume	6
Issue number	12
DOIs	https://doi.org/10.1177/1934578x1100601234
State	Published - Dec 2011
Externally published	Yes

Keywords

Antimicrobial
Cancer
Cytotoxic
Mexican medicinal plants
Multidrug-resistance
Peripheral blood mononuclear cells

ASJC Scopus subject areas

Pharmacology
Drug Discovery
Plant Science
Complementary and alternative medicine

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10.1177/1934578x1100601234

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Jacobo-Salcedo, M. D. R., Alonso-Castro, A. J., Salazar-Olivo, L. A., Carranza-Alvarez, C., Gonzaĺez-Espińdola, L. A., Domińguez, F., Maciel-Torres, S. P., Garciá-Lujan, C., Gonzaĺez-Martińez, M. D. R., Goḿez-Sańchez, M., Estrada-Castilloń, E., Zapata-Bustos, R., Medellin-Milań, P., & Garciá-Carrancá, A. (2011). Antimicrobial and cytotoxic effects of Mexican medicinal plants. Natural Product Communications, 6(12), 1925-1928. https://doi.org/10.1177/1934578x1100601234

Jacobo-Salcedo, MDR, Alonso-Castro, AJ, Salazar-Olivo, LA, Carranza-Alvarez, C, Gonzaĺez-Espińdola, LA, Domińguez, F, Maciel-Torres, SP, Garciá-Lujan, C, Gonzaĺez-Martińez, MDR, Goḿez-Sańchez, M, Estrada-Castilloń, E, Zapata-Bustos, R, Medellin-Milań, P & Garciá-Carrancá, A 2011, 'Antimicrobial and cytotoxic effects of Mexican medicinal plants', Natural Product Communications, vol. 6, no. 12, pp. 1925-1928. https://doi.org/10.1177/1934578x1100601234

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title = "Antimicrobial and cytotoxic effects of Mexican medicinal plants",

abstract = "The antimicrobial effects of the Mexican medicinal plants Guazuma ulmifolia, Justicia spicigera, Opuntia joconostle, O. leucotricha, Parkinsonia aculeata, Phoradendron longifolium, P. serotinum, Psittacanthus calyculatus, Tecoma stans and Teucrium cubense were tested against several human multi-drug resistant pathogens, including three Gram (+) and five Gram (-) bacterial species and three fungal species using the disk-diffusion assay. The cytotoxicity of plant extracts on human cancer cell lines and human normal non-cancerous cells was also evaluated using the MTT assay. Phoradendron longifolium, Teucrium cubense, Opuntia joconostle, Tecoma stans and Guazuma ulmifolia showed potent antimicrobial effects against at least one multidrug-resistant microorganism (inhibition zone > 15 mm). Only Justicia spicigera and Phoradendron serotinum extracts exerted active cytotoxic effects on human breast cancer cells (IC50≤30 μg/mL). The results showed that Guazuma ulmifolia produced potent antimicrobial effects against Candida albicans and Acinetobacter lwoffii, whereas Justicia spicigera and Phoradendron serotinum exerted the highest toxic effects on MCF-7 and HeLa, respectively, which are human cancer cell lines. These three plant species may be important sources of antimicrobial and cytotoxic agents.",

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doi = "10.1177/1934578x1100601234",

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AU - Jacobo-Salcedo, Maria Del Rosario

AU - Alonso-Castro, Angel Josabad

AU - Salazar-Olivo, Luis A.

AU - Carranza-Alvarez, Candy

AU - Gonzaĺez-Espińdola, Luis Ańgel

AU - Domińguez, Fabiola

AU - Maciel-Torres, Sandra Patricia

AU - Garciá-Lujan, Concepcioń

AU - Gonzaĺez-Martińez, Marisela Del Rocio

AU - Goḿez-Sańchez, Maricela

AU - Estrada-Castilloń, Eduardo

AU - Zapata-Bustos, Rocio

AU - Medellin-Milań, Pedro

AU - Garciá-Carrancá, Alejandro

PY - 2011/12

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AB - The antimicrobial effects of the Mexican medicinal plants Guazuma ulmifolia, Justicia spicigera, Opuntia joconostle, O. leucotricha, Parkinsonia aculeata, Phoradendron longifolium, P. serotinum, Psittacanthus calyculatus, Tecoma stans and Teucrium cubense were tested against several human multi-drug resistant pathogens, including three Gram (+) and five Gram (-) bacterial species and three fungal species using the disk-diffusion assay. The cytotoxicity of plant extracts on human cancer cell lines and human normal non-cancerous cells was also evaluated using the MTT assay. Phoradendron longifolium, Teucrium cubense, Opuntia joconostle, Tecoma stans and Guazuma ulmifolia showed potent antimicrobial effects against at least one multidrug-resistant microorganism (inhibition zone > 15 mm). Only Justicia spicigera and Phoradendron serotinum extracts exerted active cytotoxic effects on human breast cancer cells (IC50≤30 μg/mL). The results showed that Guazuma ulmifolia produced potent antimicrobial effects against Candida albicans and Acinetobacter lwoffii, whereas Justicia spicigera and Phoradendron serotinum exerted the highest toxic effects on MCF-7 and HeLa, respectively, which are human cancer cell lines. These three plant species may be important sources of antimicrobial and cytotoxic agents.

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KW - Cancer

KW - Cytotoxic

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KW - Multidrug-resistance

KW - Peripheral blood mononuclear cells

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Antimicrobial and cytotoxic effects of Mexican medicinal plants

Abstract

Keywords

ASJC Scopus subject areas

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