Antimicrobial and cytotoxic effects of Mexican medicinal plants

Maria Del Rosario Jacobo-Salcedo, Angel Josabad Alonso-Castro, Luis A. Salazar-Olivo, Candy Carranza-Alvarez, Luis Ańgel Gonzaĺez-Espińdola, Fabiola Domińguez, Sandra Patricia Maciel-Torres, Concepcioń Garciá-Lujan, Marisela Del Rocio Gonzaĺez-Martińez, Maricela Goḿez-Sańchez, Eduardo Estrada-Castilloń, Rocio Zapata-Bustos, Pedro Medellin-Milań, Alejandro Garciá-Carrancá

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


The antimicrobial effects of the Mexican medicinal plants Guazuma ulmifolia, Justicia spicigera, Opuntia joconostle, O. leucotricha, Parkinsonia aculeata, Phoradendron longifolium, P. serotinum, Psittacanthus calyculatus, Tecoma stans and Teucrium cubense were tested against several human multi-drug resistant pathogens, including three Gram (+) and five Gram (-) bacterial species and three fungal species using the disk-diffusion assay. The cytotoxicity of plant extracts on human cancer cell lines and human normal non-cancerous cells was also evaluated using the MTT assay. Phoradendron longifolium, Teucrium cubense, Opuntia joconostle, Tecoma stans and Guazuma ulmifolia showed potent antimicrobial effects against at least one multidrug-resistant microorganism (inhibition zone > 15 mm). Only Justicia spicigera and Phoradendron serotinum extracts exerted active cytotoxic effects on human breast cancer cells (IC50≤30 μg/mL). The results showed that Guazuma ulmifolia produced potent antimicrobial effects against Candida albicans and Acinetobacter lwoffii, whereas Justicia spicigera and Phoradendron serotinum exerted the highest toxic effects on MCF-7 and HeLa, respectively, which are human cancer cell lines. These three plant species may be important sources of antimicrobial and cytotoxic agents.

Original languageEnglish (US)
Pages (from-to)1925-1928
Number of pages4
JournalNatural Product Communications
Issue number12
StatePublished - Dec 2011
Externally publishedYes


  • Antimicrobial
  • Cancer
  • Cytotoxic
  • Mexican medicinal plants
  • Multidrug-resistance
  • Peripheral blood mononuclear cells

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine


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